血尿酸与代谢危险因素交互作用对高血压的影响

Interaction between serum uric acid and metabolic risk factors in relation to hypertension

探讨血尿酸与高血压的关系,评估代谢危险因素与血尿酸交互作用对高血压风险的影响.检测8 415名健康体检人群的血压及其他相关指标,进行统计分析.高血压风险随血尿酸水平的升高而增加（P＜0.01）.血尿酸与年龄、高密度脂蛋白胆固醇（HDL-C）交互作用对高血压风险的影响有统计学意义（交互作用P值分别为0.012,0.001）.血尿酸水平与高血压风险有关,年龄和HDL-C水平可能影响这种联系.

The relationship between serum uric acid（SUA） and hypertension was investigated and the interactions of SUA with metabolic risk factors was assessed. Blood pressure and biomarkers features were evaluated for all the8 415 individuals from a community-based health examination survey in Xuzhou, and the statistical analysis was made. Raised blood pressure was associated with increased SUA concentration（P〈0.01）. Age and high density lipoprotein cholesterol（HDL-C） significantly interacted with SUA（P for interaction=0.012 and 0.001, respectively）. There is significant association between SUA and hypertension, which may be affected by age and HDL-C levels.