体内高糖环境下肝脏卵圆细胞的功能研究

The function of hepatic oval cells under high glucose condition in vivo

以链脲佐菌素（STZ）诱导肝脏卵圆细胞模型大鼠体内高血糖,检测肝脏中胰岛素和转录因子（PDX-1、Nkx6.1）mRNA的表达.可见体内高糖环境下,肝脏胰岛素染色阳性,Nkx6.1和Pdx1mRNA表达明显增强,并有胰岛素1 mRNA的表达.提示高糖环境下,肝脏卵圆细胞可分化为胰岛素分泌细胞.

Rat hepatic oval cell model was induced by hyperglycemia and streptozotocin in vivo. Expression of insulin and mRNA expression of pancreatic transcription factors（Nkx6.1, PDX-1） were carried out. It showed that under high glucose, liver tissues were positive for insulin staining, the expression of Nkx6.1 and Pdx-1mRNA was significantly enhanced, and insulin-1mRNA was found to be expressed. The result suggests that under high glucose, hepatic oval cells can differentiate into insulin-producing cells.