P-选择素与冠心病及冠心病合并糖尿病相关性研究

The correlative study on P-selectin levels with coronary heart diseases and coronary heart disease with diabetes

目的:观察P-选择素(P-selectin,Ps)在冠心病及冠心病合并糖尿病患者血清中的含量,探讨其与血糖之间的关系。方法:选择2007年10月～2009年10月于我科住院观察的冠心病患者96例,其中,稳定型心绞痛组(SA)28例和不稳定型心绞痛组(UAP)24例,稳定型心绞痛合并糖尿病组(SA+T2DM)20例和不稳定型心绞痛组合并糖尿病组(UAP+T2DM)24例,20例健康人为对照组,应用酶联免疫法测定血清中P-selectin水平。结果:各组一般资料除BMI外,其余指标差异均无统计学意义,具有可比性。与对照组相比,其余四组患者Ps均显著升高,差异有统计学意义(F=9.365,P<0.05),且UAP组患者血清Ps水平均高于相应SA组患者(P=0.031、P=0.012)。SA+T2DM和UAP+T2DM两组P-选择素与HbA1c、FPG成正相关(r=0.316,P=0.041;r=0.341,P=0.037;r=0.347,P=0.032;r=0.384,P=0.020),而对照组与SA及UAP组的Ps水平与血糖指标之间无相关关系。结论:冠心病患者血清Ps水平升高与冠心病病变程度有关,高血糖在血小板活化的发展中可能起一定作用。

Objective： To investigate the changes of P-selectin level in coronary heart disease（CHD）,coronary heart disease complicating diabetes mellitus（DM）.The relationship of P-selectin and blood glucose in CHD were Analyzed.Methods： 96 patients who were in our hospital from October 2007 to October 2009 were selected,28 cases were stable angina pectoris（SA）,24 cases were unstable angina pectoris（UAP）,24 cases were stable angina pectoris complicating diabetes（SA＋T2DM） and 20 cases were unstable angina pectoris complicating diabetes（UAP＋T2DM）.20 healthy persons were chosen as control group.The levels of P-selectin of serum were measured by enzyme linked immunosorbent assay（ELISA） technique.Results： The general information in each group had no statistical significance except BMI.Compared with the control group,the level of P-selectin in other four groups were significantly increased（F=9.365,P0.05）;and P-selectin levels in UAP group were higher than that in corresponding group of SA.The P-selectin level in SA＋T2DM and UAP＋T2DM group correlated with HbA1c and FPG（r=0.316,P=0.041;r=0.341,P=0.037;r=0.347,P=0.032;r=0.384,P=0.020）,whereas there was no correlativity between Ps and blood glucose in other three groups.Conclusion： The arising of P-selectin levels in serum might reflect the severity of coronary heart disease;hyperglycemia may play a role in activating the platelet in patients with CHD.