厄贝沙坦对老年高血压左心室肥厚及舒张功能的影响

Effects of Irbesartan on left ventricular hypertrophy and diastolic function in elderly patients with hypertension

目的:观察厄贝沙坦对老年高血压左室肥厚(LVH)及舒张功能的影响。方法:78例患者口服厄贝沙坦150 mg,每天1次,治疗32周,分别测量血压以及彩色多普勒超声检测左室舒张末内径(LVDd)、左室舒张期室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左室心肌重量指数(LVMI)、左室射血分数(LVEF)、二尖瓣口舒张早、晚期血流峰值速度E/A比值。结果:治疗后血压(SBP/DBP)、LVDd、IVST、LVPWT、LVMI均明显下降(P<0.05),LVEF、E/A均明显上升(P<0.05)。结论:厄贝沙坦不仅能有效降低老年人高血压和逆转其左心室肥厚,而且能明显改善其左心舒张功能。

Objective： To observe the effect of Irbesartan on left ventricular hypertrophy and left ventricular diastolic function in elderly patients.Methods： 78 cases of elderly patients with left ventricular hypertrophy were given Irbesartan 150 mg once daily for 32 weeks.left ventricular diastolic diameter（LVDd）,left ventricalar septal thick（IVST）,left ventricular posterior wall thick（LVPWT）,left ventricular ejection fraction（LVEF）,left ventricular mass index（LVMI）,the ratio of peak flow velocity in early diastolic to that at atrial contraction（E/A） were measured by Doppler echocardiography.Results： After 12 months treatment,blood pressure（SBP/DBP）,LVDd,IVST,LVPWT and LVMI decreased significantly（P0.05）,LVEF,E/A increased significantly（P0.05）.Conclusion： Irbesartan not only can decrease the hypertension and remodel the hypertrophied ventricle,but also improve left ventricular diastolic function.