丹红注射液治疗不稳定型心绞痛

Danhong injection in the treatment of unstable angina

目的:观察丹红注射液治疗不稳定型心绞痛的疗效。方法:将50例不稳定型心绞痛患者随机分为治疗组与对照组各25例。对照组给予常规治疗,即给予硝酸酯类药、阿司匹林、美托洛尔、他汀类调脂药、血管紧张素转换酶抑制剂等。治疗组在对照组基础上给予丹红注射液静脉滴注治疗,即5%葡萄糖或生理盐水250 ml+丹红注射液20 ml,1次/d。两组均观察2周。结果:治疗组总有效率为92.0%,对照组总有效率为72.0%,两组总有效率比较,差异具有统计学意义(P<0.05);治疗组和对照组在治疗后心绞痛发作次数、24 h心肌缺血时间、心绞痛单次持续时间均有所降低(P<0.05),但治疗组较对照组改善更为明显,且差异有统计学意义(P<0.05);两组治疗期间无变态反应及其他不良反应。结论:丹红注射液治疗不稳定型心绞痛,疗效确切,不良反应少,值得推广。

Objective： To observe the curative effect of Danhong injection in the treatment of unstable angina.Methods： 50 cases of patients with unstable angina were randomly divided into treatment group and control group,25 cases each group.Control group was given conventional treatment,including nitrates,Aspirin,Metoprolol,statins and angiotensin converting enzyme inhibitors.The treatment group was treated with Danhong Injection on the basis of control group,Danhong Injection 20 ml＋5% glucose or normal saline 250 ml,intravenous drip,once a day.The two groups were all given two weeks treatment and observation.Results： The total effective rate of treatment group was 92.0%,while the control group was 72.0%.There was a significant difference between the two groups in total effective rate（P0.05）.After treatment,the times of angina attacks,myocardial ischemia time in 24 h and the duration of a single angina had reduced in both groups（P0.05）.But the curative effect of treatment group was more apparent than that of control group,which was significant（P0.05）.During the treatment,there was no allergic reaction or other adverse reactions.Conclusion： Danhong Injection may have evident effect and high security in the treatment of unstable angina,which is worthy of popularization.