HIV感染者口腔白色念珠菌和光滑念珠菌溶血性的比较

Comparison of the hemolytic activity between Candida albicans and Candida glabrata isolates in oral cavity of HIV-infected patients

目的:探讨HIV感染者口腔白色念珠菌和光滑念珠菌分离株的溶血性,及其与宿主机体免疫力(用CD4细胞计数表示)的关系。方法:40株白色念珠菌和40株光滑念珠菌按单一感染或是否与光滑(白色)念珠菌混合感染及CD4细胞计数的高低进行分组,采用羊血培养基法检测其溶血活性,并进行组间比较。结果:40株白色念珠菌和40株光滑念珠菌溶血活性均为阳性(100%),且光滑念珠菌的溶血性高于白色念珠菌。结论:溶血性是念珠菌的重要毒力因子,HIV感染者口腔光滑念珠菌溶血性高于白色念珠菌。

Objective To investigate the hemolytic activity of Candida albican and Candida glabrata isolates in oral cavity of HIV-infected patients, and its relationship with the immunity of the patients. Methods Forty Candida albican and 40 Candida glabrata isolates were grouped by infection types and CD4 cell count. The hemolytic activity was measured by sugar-enriched sheep blood agar medium. Results The hemolytic activity of Candida glabrate was significantly higher than that of Candida albicans （P 〈 0.01 ）. Conclusion Hemolytic activity is an important virulence factor of Candida. The hemolytic activity of Candida glabrata was higher than that of Candida albicans in oral cavity of HIV-infected patients.