骨保护素与代谢综合征

Osteoprotegerin and metabolic syndrome

骨保护素（OPG）是一种分泌型糖蛋白，属于肿瘤坏死因子受体超家族成员，不仅在骨代谢过程中起重要作用，而且是重要的血管调节因子，能够保护血管内皮细胞，抑制血管钙化和动脉粥样硬化。代谢综合征（MS）包括腹型肥胖、胰岛素抵抗、血脂异常、高血糖、高血压等。MS各组分均为心血管疾病的危险因素，2型糖尿病患者血OPG水平明显升高，但是OPG与MS其他各组分之间的关系目前还存在争议。

Osteoprotegcrin（OPG） is a secreted glycoprotein belonging to the tumor necrosis factor （TNF） receptor family. It has been identified as a regulator of bone resorption. Recent studies show that OPG also acts as an important regulatory molecule in the vasculature. It could not only protect the vascular endothelial cells, but also inhibit vascular calcification and atherosclerosis. Metabolic syndrome（MS） consists of central obesity,iusulin resistance, dyslipidemia, hyperglycemia and hypertension, etc. Each component of MS is a risk factor in cardiovascular diseases. Elevated levels of plasma OPG were reported in patients with type 2 diabetes mellitus,but there is conflicting evidence about whether there is a general relationship between circulating OPG levels and other components of MS.