老年人膝关节骨性关节炎影响因素分析研究

Study of the influential factors on osteoarthritis of the knee in the elderly

目的通过对老年人群的膝关节骨性关节炎(OA)发病危险因素进行研究,为膝关节骨性关节炎的预防和治疗提供依据。方法选取经过确诊的1380例OA病例和1500例对照病例,进行病例对照研究;采用非条件Logistic回归分析,筛选出影响OA的危险因素。结果多因素分析结果显示:性别(OR=2.447,95%CL:1.767～3.127)、体质指数(OR=2.469,95%CL:1.911～3.028)、膝关节史(OR=3.343,95%CL:2.289～4.398)、潮湿(OR=4.586,95%CL:2.930～6.242)、阴暗(OR=5.099,95%CL:3.280～6.918)、低强度锻炼(OR0.468,95%CL:0.258～0.678)、职业运动锻炼(OR=7.374,95%CL:4.830～9.918)、关节负重(OR=5.766,95%CL:3.342～8.191)、盘坐习惯(OR=4.600,95%CL:2.924～6.276)。结论膝关节骨性关节炎的发病受性别、肥胖、膝关节史、潮湿阴暗、低强度的运动习惯、职业运动锻炼、关节负重、盘坐习惯等因素的影响。

Objective To study the risk factors of knee osteoarthritis （OA） in the elder people, for providing evidence for preventing and treating OA disease. Methods Clearly diagnosed 1380 OA patients and 1500 control cases were selected to carry out a case-control study. The risk factors of OA were screened with non-condition logistic regression analysis. Results Multiple factor analysis showed that sex （ OR = 2.447, 95% CL 1.767-3. 127）, BMI （OR =2.469, 95%CL 1.911-3.028）, knee joint history （OR = 3. 343, 95% CL 2. 289-4. 398）, moist （OR =4.586, 95% CL 2. 930-6. 242）, gloomy （OR =5.099, 95% CL 3. 280-6. 918） , low intensity exercise （ OR = 0. 468, 95% CL 0. 258-0. 678） , occupational sport training （ OR = 7. 374,95% CL 4. 830-9. 918）, loading of the knee joint （ OR = 5. 766, 95% CL 3. 342- 8. 191 ） , and special sitting habit （ OR = 4. 600, 95% CL 2. 924-6. 276 ） were related. Conclusion The main risk factors of OA were sex, obesity, knee joint history, moist and gloomy, low intensity exercise, occupational sport training, loading of the knee joint, and the special sitting habit.