高原移居人群肺功能与血浆一氧化氮测定结果分析

RELATIONSHIP BETWEEN LUNG FUNCTION AND PLASM NO IN IMMIGRANTS EXPOSED TO HIGH ALTITUDE

目的：探讨高原移居人群低氧初期和居住６个月后的动态肺功能与血浆一氧化氮之间的内在关系，充分认识低氧环境中肺通气功能的变化和调节过程，为急性高原病的防治寻求新的途径；方法：采用美国产ＥＳ８００ 肺功能仪对同一群体的２０名男性健康青年于上山前（海拔１ ４００ｍ ）和进驻海拔５ ３８０ｍ １０ 天及居住６ 个月后在静息状态下进行动态肺功能及血浆一氧化氮的测定；结果：海拔５ ３８０ｍ 移居１０ 天与海拔１ ４００ｍ 比较，ＦＶＣ（用力肺活量）、ＦＥＦ２５％ ～７５％ （用力呼气中期流速）、ＦＥＶ１（１ 秒钟用力呼气量）及ＭＶＶ（最大通气量）显著增加（Ｐ＜ ０．０１ 或Ｐ＜ ０．０５），血浆ＮＯ（一氧化氮）含量显著降低（Ｐ＜ ０．０１），海拔５ ３８０ｍ 居住６ 个月与移居１０天比较，ＦＶＣ、ＭＶＶ显著降低（Ｐ＜ ０．０５），血浆ＮＯ含量显著增多（Ｐ＜ ０．０５）；海拔５ ３８０ｍ 居住６ 个月与海拔１ ４００ｍ 比较ＦＶＣ、ＦＥＦ２５％ ～７５％ 、ＦＥＶ、ＭＶＶ显著增加（Ｐ＜ ０．０１ 或Ｐ＜ ０．０５），血浆ＮＯ显著降低（Ｐ＜０．０５）；海拔５ ３８０ｍ 移居６ 个月与移居１０ 天比较，ＰＥＦ（最大呼气流量）、ＦＥＶ１％ （１ 秒钟用力呼气量占用肺活?

To survey the relationship between pulmonary function and plasm NO in immigrants exposed to high altiude(5 380m) to explore a new way of treatment and prevention of AMS.Methods:Pulmonary function and plasm NO in 20 healthy male (19～27years old) were examined in rest by ES800 lung function unit,USA,pre-and 10 days and 6 months post-altitude.Results:Level of FVC,FEF25%～75%,FEV 1 and MVV in 10 days post-altirude were significantly increased,as compared with pre-altitude (P <0.01 or 0.05);level of plasm NO was decreased ( P <0 01).FVC and MVV were decreased( P <0.05 ) but level of plasm NO was increased obviously (P <0.05) ,as 6 months vs 10 days post-altitude;FVC,FEF25%～75%,FEV 1 and MVV were obviously increased( P < 0.01 0r 0.05) ,level of plasm NO was decreased( P < 0.05) ,as 6 months post-altitude vs before altitude.NO difference in PEF and FEV 1% between 6 months and 10 days post-altitude.Conclusions:Pulmonary ventilation increase and level of plasm NO decrease in beginning of altitude exposure.When the time of postaltitude is prolongged,the ventilation lows progressively or the level of plasm NO arise but their value is still higher than or lower than that pre-altitude.$$$$