摘要
目的：临床试验并确定硫普罗宁针剂治疗慢性病毒性肝炎的有效性及安全性。方法：采用随机、对照试验方法，把适应证患者分为两组：试验组120例，静滴硫普罗宁针剂200mg／d；对照组60例，静滴强力宁针剂40mg／d。疗程均为4周，停药后随访半年。结果：试验组总有效率为68.3％，明显高于对照组的46.7％（P＜0．05）。轻度皮肤反应5例，不良反应发生率为4．2％。结论：硫普罗宁针剂对慢性病毒性肝炎具有确切的肝功能改善治疗作用，安全性亦较好。
A clinical trial for determination of the efficacy and side effects of tiopronin in treatment of chronic viral hepatitis. METHODS: The randomized and controlled study was conducted in 180 patients with chronic hepatitis. They were divided into active group(n = 120) to receive 200 mg daily tiopronin injection, and control group(n = 60)to receive Qianglining injection. Both groups were treated for 4 weeks. RESULTS: The total effective rate of active group (68. 3 % ) is significantly higher than that(46. 7 % )of control group(P < 0. 05 ) with an adverse reaction rate of 4. 2 %.
出处
《中国新药杂志》
CAS
CSCD
1999年第12期831-834,共4页
Chinese Journal of New Drugs
关键词
硫普罗宁
慢性
病毒性肝炎
肝功能
药理
治疗
Tiopronin
Chronic viral hepatitis
Liver function
Clinical pharmacology
