唾液IgG抗体测定诊断幽门螺杆菌感染

Diagnosis of Helicobacter pylori infection by detecting the IgG antibody in saliva

目的 探讨唾液抗HpIgG测定对Hp感染的诊断价值。方法 用ELISA法测定 5 4例Hp阳性及 15例Hp阴性患者唾液内抗HpIgG ,并与血清抗体测定结果相比较。结果 唾液抗HpIgG对Hp感染诊断的敏感性为 90 7% ,特异性为 80 % ,准确性为 88 4% ,阳性预测值 94 2 % ,阴性预测值 70 6 % ,与血清测定结果接近 (分别为 92 6 % ,86 7% ,91 3 % ,96 1%和 76 5 % ) ,唾液抗HpIgG与血清内抗HpIgG滴度显著正相关 (r=0 6 73 7,P <0 .0 0 1)。结论 唾液抗HpIgG测定诊断Hp感染有较好应用价值。

Aim To assess the salivary diagnosis of H. pylori infection. Methods Salivary and serum IgG antibody to H. plyori was tested by ELISA in 54 patients with H pylori infection and 15 patients without H. pylori infection. Results The sensitivity and specificity of salivary H. pylori IgG were 90.7% and 80% respectively; the positive and negative predictive values were 94.2% and 70.6% respectively; and the accuracy 88.4%. The corresponding figures for serum H. pylori IgG were 92.6% and 86.7%;96.1% and 76.5%; and 91.3%. The titers of salivary H pylori IgG closely correlated with that of serum H. pylori IgG.Conclusion This study suggests that salivary H. pylori IgG is an accurate indicator of gastric H. pylori infection.