巨齿蛇毒发色底物法检测重症肝病患者血浆凝血酶原活性的研究

The study on plasma factor Ⅱ coagulant activity by echis carinatus venom chromogenic substrate assay of serious hepatitis disease

目的：评估血浆凝血酶原活性在重症肝病早期诊断中的应用价值。方法：采用巨齿蛇毒发色底物法检测了１００例献血员和１１５例重症肝病患者的ＦⅡ：ＣＡ，并同步检测预示重症肝病的其他指标。结果：ＦⅡ：ＣＡ正常参考范围（８５．０－１３１．０）％，重症肝病患者的ＦⅡ：ＣＡ与正常对照及预示重症肝病的其他指标比较均具有显著性差异。

Objective:To evaluate application of plasma (actor Ⅱ coagulant activity (FⅡ:CA) in the early diagnosis of serious hepatitis (SH) disease.Methods:Echis carinatus venon chromogenic substrate assay (ECVCSA) was in the detection of FⅡ:CA in the plasma of 100 helth subjects and in 115 patients with SH and other terms of SH. Result:nonnal FⅡ:CA referene levels were (85.0～131.0%).FⅡ:CA of SH was more significantly higher than levels of normal group and other terms levels of SH. Conclusion:The detection of FⅡ:CA may be one of the terms of SH in the early diagnosis.