动脉介入治疗及经皮穿刺消融综合治疗肝脏肿瘤的临床研究

Intraarterial chemotherapy combined with microwave ablation in treatment of hepatocellular carcinoma

目的研究动脉介入治疗及经皮穿刺消融综合治疗肝脏肿瘤的临床疗效。方法 90例肝脏肿瘤患者随机分为单纯介入治疗组和介入治疗联合消融治疗两组各45例。单纯介入治疗组选择5-FU 1.0g;ADM 60 mg;DDP 80 mg;HCPT 20 mg动脉化疗并碘油栓塞,每月1次共3次。联合消融治疗组在介入治疗之后1周行微波凝固治疗(MTC),微波治疗后同时行无水酒精注射。结果联合治疗组在AFP下降、B超周边血流减少、肿瘤生长速度减慢方面明显好于单纯介入组(P<0.05)。结论介入治疗联合微波凝固治疗和无水酒精注射综合治疗肝脏肿瘤明显提高疗效,未增加不良反应。

Objective To evaluate the therapeutic effect of intraarterial chemotherapy combined with microwave ablation for hepatocellular carcinoma. Methods Ninety cases with hepatocellular carcinoma were randomly divided into two groups.The control group（n=45） received intraarterial chemotherapy（TACE,5-FU 1.0 g,ADM 60 mg,DDP 80 mg and HCPT 20 mg） plus embolization with iodipin once a month for three times.Patients in combination group（n=45） were treated by TACE combined with anhydrous alcohol injection（PEIT） and microwave ablation.The serum AFP,peripheral blood flow and tumor growth were evaluated. Results The indicators（serum AFP levels,peripheral blood flow and tumor size） in combination group were all better than those in control group（P0.05）. Conclusion Intraarterial chemotherapy combined with microwave ablation can improve the therapeutic effect in patients with hepatocellular carcinoma,not increasing side effects.