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microRNA在肿瘤诊治中的进展 被引量：3

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摘要 microRNAs（miRNAs）是一类长度约 18-26nt的非编码单链小分子 RNAs,是由具有发夹结构的约70-90个碱基大小的单链RNA前体经过Dicer酶加工后形成,通过与靶基因的3＇-UTR的配对,促进mRNA的降解或抑制mRNA的翻译从而抑制其靶基因的表达.虽然miRNA最初在线虫研究中被发现[1],但在随后的研究中证实miRNA几乎存在于所有的真核动物中,miRNA广泛参与了生物体多种生理过程,如个体发育,细胞增殖、凋亡和分化,代谢与应激反应的调节,肿瘤的形成等[2].
作者 王福飞 李勇
机构地区 南昌大学第一附属医院普外
出处 《江西医药》 CAS 2011年第6期580-582,共3页 Jiangxi Medical Journal
关键词 MICRORNA 肿瘤发生 诊断 基因治疗
分类号 R730.4 [医药卫生—肿瘤]
  • 相关文献

参考文献24

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二级参考文献17

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共引文献2

同被引文献32

  • 1Nam EJ,Yoon H,Kim SW,et al.MicroRNA expression profiles in serous ovarian carcinomaClinical Cancer Research,2008.
  • 2Nicholson K M,Anderson N G.The protein kinase B/Akt signalling pathway in human malignancyCell Signaling,2002.
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  • 7Zhong M,Ma X,Sun C, et al.MicroRNAs reduce tumor growth and contribute to enhance cytotoxicity induced by gefitinib in non-small cell lung cancerChemico Biological Interactions,2010.
  • 8Suzuki H I,Yamagata K,Sugimoto K, et al.Modulation of microRNA processing by p53.Nature,2009.
  • 9Mohit Sachdeva,Qian Liu,Julia Cao, et al.Negative regulation of miR-145by C/EBP-b through the Akt pathway in cancer cellsNucleic Acids Research,2012.
  • 10Noguchi S,Yasui Y,Iwasaki J,et al.Replacement treatment withmicroRNA-143 and-145 induces synergistic inhibition of thegrowth of human bladder cancer cells by regulating PI3K/Akt andMAPK signaling pathwaysCancer Letters,2013.

引证文献3

二级引证文献9

江西医药
2011年 第6期

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