血浆脑钠肽在急性冠状动脉综合征中的临床应用进展

Clinical Application of Plasma Brain Natriuretic Peptide in Acute Coronary Syndromes

脑钠肽是主要由心室肌细胞分泌的一种心脏神经激素,是心功能不全时机体的代偿机制之一。近年来研究表明,心肌缺血同样能够引起脑钠肽水平的升高,血浆脑钠肽与急性冠脉综合征的关系已经引起人们的关注。脑钠肽与NYHA分级和左室射血分数间存在较好的相关性,可作为预测急性冠脉综合征心室重塑、冠脉病变程度的有效指标,是急性冠脉综合征的独立预后因子,并作为高敏C反应蛋白、肌酸激酶同工酶和肌钙蛋白I等生化指标的有益补充,为急性冠脉综合征提供有价值的辅助诊断。

Brain natriuretic peptide（BNP） is a cardiac neural hormone,secreted by cardiac myocytes,and one of the body＇s compensatory mechanisms during heart failure.Recent studies have shown that myocardial ischemia can cause elevated BNP levels.BNP may be an effective indicator to predict ventricular remodeling and the extent of coronary artery disease in acute coronary syndrome patients.It is also an independent predictors of acute coronary syndromes,and a useful addition to biochemical index such as hs-CRP,CK-MB and cTnI.This article reviews BNP＇s role in ACS and how it may be used as a diagnostic tool.