期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

硫酸氨基葡萄糖联合塞来昔布治疗骨关节炎疗效观察 被引量：3

原文传递
导出
摘要 目的:观察硫酸氨基葡萄糖联合塞来昔布治疗骨关节炎(OA)的临床疗效。方法:选择OA 106例,随机分为观察组55例和对照组51例;观察组给予硫酸氨基葡萄糖联合塞来昔布治疗,对照组给予美洛昔康治疗;两组均治疗6周并停药4周后采用Le-quesne指数评价疗效,并记录不良反应。结果:(1)观察组治疗前Lequesne评分为(18.2±7.6)分,治疗6周并停药4周后降至(10.6±6.7)分;对照组治疗前Lequesne评分为(17.8±7.7)分,治疗6周并停药4周后降至(15.3±6.3)分;两组比较,差异均显著(P<0.05)。(2)观察组服药期间出现胃肠道不适2例,便秘1例,不良反应发生率为5.4%;对照组服药期间出现胃肠道不适6例,轻度腹痛2例,恶心2例,不良反应发生率为19.6%;两组比较,差异均显著(P<0.05)。(3)两组各项实验室检查指标治疗前后均无显著变化(P>0.05)。结论:硫酸氨基葡萄糖联合塞来昔布治疗OA疗效较好,且不良反应少。
作者 宋科冉 赵庆 王富 于红
机构地区 解放军总医院
出处 《人民军医》 2011年第7期583-584,共2页 People's Military Surgeon
关键词 硫酸氨基葡萄糖 塞来昔布 骨关节炎
分类号 R658.1 [医药卫生—外科学]
  • 相关文献

参考文献11

  • 1Buckwalter J A, Starfish WD, Rosier RN,et al. The increasing need for nonoperative treatment of patients with osteoarthritis[J]. Clin Or- thop Relat Res, 2001,(385) :36-45.
  • 2Chan FK, Lanas A, Scheiman I,et al. Celeeoxib versus omeprazole and dielofenae in patients with osteoarthritis and rheumatoid arthritis (CONDOR) : A randomised triM[J]. Lancet, 2010,376(9736) : 173- 179.
  • 3Towheed TE. Published Meta-analyses of pharmacological therapies for osteoarthritis[J]. Osteoarthritis Cartilage, 2002,10 (11) : 836- 837.
  • 4Altman R. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthrltis of the knee:Diagnostlc and Therapeutic Criteria Committee of the American Rheumatism As- sociation[J]. Arthritis Rheum, 1986,29(8) : 1039-1049.
  • 5Lequesne M G, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J].J Rheumatol Suppl, 1991,27: 16-18.
  • 6Lindow TE. Osteoarthritis: New insights[J]. Ann Intern Med, 2002,136(1) : 86-88.
  • 7Reginster JY, Deroisy R, Rovati LC,et al. Long-term effects of glu- cosamine sulphate on osteoarthritis progression: A randomised place- bo-controlled clinical trial[J].Lancet,2001,357(2) :251-256.
  • 8Pavelka K,Gatterova J,Olejarova M,et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study[J]. Arch Intern Med, 2002, 162(18) :2113-2123.
  • 9McAlindon T, Formica M, Lavaller M, et al. Effectiveness of glu- cosamine for symptoms of knee osteoarthritis: Results from an inter- net-based randomized double-blind controlled trial[J]. Am J Med, 2004,117 (9) : 643-649.
  • 10邱贵兴,翁习生,张克,周乙雄,娄思权,王以朋,李为,张洪,刘岩.盐酸/硫酸氨基葡萄糖治疗骨关节炎的平行对照临床研究[J].中华医学杂志,2005,85(43):3067-3070. 被引量：92

二级参考文献24

  • 1徐苓,Michael C Nevitt,Yuqing Zhang,余卫,Piran Alibadi,David T Felson.北京城区老年人膝、髋和手骨关节炎的患病率及其与美国白人患病率的比较研究[J].中华医学杂志,2003,83(14):1206-1209. 被引量：62
  • 2Brief AA, Maurer SG, Di Cesare PE. Use of glucosamine and chondroitin sulfate in the management of osteoarthritis. J Am Acad Orthop Surg, 2001, 9:71-78.
  • 3Gaby AR. Natural treatments for osteoarthritis. Altern Med Rev, 1999, 4: 330-341.
  • 4Oegema TR Jr, Deloria LB, Sandy JD, et al. Effect of oral glucosamine on cartilage and meniscus in normal and chymopapain-injected knees of young rabbits. Arthritis Rheum, 2002, 46: 2495-2503.
  • 5Bassleer C, Rovati L, Franchimont P. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis Cartilage, 1998, 6:427-434.
  • 6Fenton JI, Chlebek-Brown KA, Peters TL, et al. Glucosamine HCl reduces equine articular cartilage degradation in explant culture. Osteoarthritis cartilage, 2000, 8: 258-265.
  • 7Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Arthritis Rheum, 1986, 29: 1039-1049.
  • 8Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints. J Rheumatol , 1999, 27 Suppl: 16-18.
  • 9Noack W, Fischer M, Forster KK, et al. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage, 1994, 2:51-59.
  • 10Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee Osteoarthritis. Arzneimittelforschung, 1998, 48:469-474.

共引文献122

同被引文献23

  • 1Beebe FA, Barkin RL, Barkin S. A clinical and pharmacologic review of skeletal muscle relaxants for musculoskeletal conditions [J] . Am J Ther, 2005, 12 (2) : 151-171.
  • 2Aslan Telci E, Karaduumn A. Effects of three different conservative treatments on pain, disability, quality of life, and mood in patients with cervical spondylosis [J] . Rheunuttol lnt, 2012, 32 (4) : 1033-1040.
  • 3Moseley B. Arthroscopic surgery did not provide additional benefit to physical and medical therapy for osteoarthritis of the knee[J]. J Bone Joint Surg Am,2009,91(5):1281.
  • 4Anne MD,Bernard MD,John MD. Arthroscopic surgery for knee osteoarthritis[J]. The Journal of Family Practice, 2009,58(3) : 143-145.
  • 5Moseley JB, O'Malley K, Petersen NJ ,et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee[J]. N Engl J Med, 2002,347(2) :81-88.
  • 6Richard W N. Is arthroscopic surgery a beneficial treatment for knee osteoarthritis[J]. Nature Clinical Practice, 2009,5 ( 3 ) : 122-123.
  • 7Marx RG. Arthroseopic surgery for osteoarthritis of the knee[J]? N Engl J Med,2008,359(11) : 1169-1170.
  • 8陈玮,吴春根,伍超贤,程永德.CT引导硬膜外皮质激素注射治疗神经根型颈椎病[J].介入放射学杂志,2009,18(2):128-131. 被引量：4
  • 9王久夏,李盛华.颈痛颗粒治疗神经根型颈椎病52例[J].甘肃中医,2009,22(5):9-10. 被引量：5
  • 10马骁,卡索,李丹,刘成,田勇.关节镜下有限清理治疗创伤性踝关节炎17例[J].人民军医,2010,53(8):599-600. 被引量：4

二级引证文献11

人民军医
2011年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部