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倍他米松-17-戊酸酯的合成研究

The Synthesis of Betamethasone 17-valerate
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摘要 以倍他米松为原料,与原戊酸三甲酯在酸催化下发生17,21-环合,然后用稀硫酸进行21-位选择性水解得到倍他米松-17-戊酸酯,产品HPLC纯度达99.42%,反应总收率达到76.4%,经IR、1H NMR、13C NMR和MS确证结构。 The Betamethasone 17-valerate was synthesized from betamethasone through acid catalysis 17,21-cyclization with trimethyl orthovalerate and 21-selective hydrolysis,the purity of product was 99.54% in HPLC analysis.The structure of product was identified by IR,1H NMR,13C NMR and MS.The synthetic process is simple,easy to control.The total yield was 76.4% and it is suitable for industrial production.
作者 张宇松 金炜华 吴定伟
机构地区 浙江仙琚制药股份有限公司
出处 《浙江化工》 CAS 2011年第7期8-9,共2页 Zhejiang Chemical Industry
关键词 倍他米松戊酸酯 糖皮质激素 合成 Betamethasone 17-valerate； Glucocorticoid； synthesis
分类号 TQ467 [化学工程—制药化工]
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参考文献6

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共引文献25

浙江化工
2011年 第7期

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