舒通胶囊对大鼠脏器的毒性试验

Toxicity Test of Shutong Capsule on Organs of Rats

目的：观察大鼠长期服用舒通胶囊对主要脏器的损害，评价其安全性。方法：80只Wistar大鼠随机分为舒通胶囊高剂量组、中剂量组、低剂量组及对照组，每组20只。给药8W后，每组取10只大鼠，禁食不禁水16h后处死大鼠，称量心、肝、脾、肺、肾、甲状腺、肾上腺、脑、睾丸、子宫、卵巢湿重，计算各脏器的脏器系数，而后将上述脏器及胃、胸腺、附睾、十二指肠、回肠、结肠制备常规病理切片进行组织学检查。余下的动物停止给药，继续观察2W，然后观察上述项目。结果：给药后8W及给药后10W，治疗组大鼠体重、脏器系数与空白对照组比较，差异无统计学意义；主要的脏器未见与药物毒性相关的形态学的改变。结论：舒通胶囊给大鼠口服在3g／（kg·d）～6．75g／（kg·d）范围内是安全的。

Objective：To observe damage of long term administration of Shutong capsule to capital organs,and to evaluate its safety. Method：80 Wistar rats were randomly divided into high dose group, middle dose group,low dose group and con- trol group. 8 w after administration, 10 rats in each group were fasted for 16 h,then they were sacrificed. The weight of heart, liver, spleen, lung, kidney, thyroid gland, adrenal gland, brain, testis, uterus, ovary of rats was weighed, then organ co- efficient was calculated. Routine pathological sections of above organs and stomach, thymus, epididymis, duodenum,ileum, colon were prepared. The left rats were stopped administrating for 2 w,then above indices were detected. Results ：8 w and 10 w after administration,there were no significant difference in weight of organ and organ coefficient of rats in treatment groups compared with control group. There were no morphologic changes related to drug toxicity in capital organs. Con- clusion ：Long term administration of Shutong capsule in dose from 3 g/（kg·d）to 6.75 g/（kg·d）was safe to rats.