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细胞因子信号转导抑制分子3与肿瘤关系的研究进展

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摘要 细胞因子与相应的受体结合可导致信号传导通路的活化,而将细胞因子的信号由胞膜传到胞浆并最终传至胞核,并引起目的基因的表达。已经发现的10余条细胞因子信号传导通路,其中Janus激酶/信号转导和转录激活子（JAK/STAT）系统涉及细胞因子的范围较为广泛。过去研究细胞因子信号的传入较多,较少观察这些信号是如何中止或衰减。
作者 邹芳芳 罗芳 熊丽霞
机构地区 南昌大学研究生院医学部 南昌大学期刊社 南昌大学基础医学院病理生理教研室
出处 《南昌大学学报（医学版）》 CAS 2011年第4期93-95,97,共4页 Journal of Nanchang University：Medical Sciences
关键词 细胞因子信号转导抑制分子3 CPG岛甲基化 Janus激酶/信号转导和转录激活子通路 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
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参考文献30

  • 1张四洋,张清富,谷雨妹,王恩华,邱雪杉.甲基化导致SOCS3表达下调与NSCLC淋巴结转移和临床病理分期相关[J].中国肺癌杂志,2008,11(2):220-225. 被引量：2
  • 2赵海丰,苏洁平,金艳红,裴海燕,姚兴伟,刘鹏,何成彦.结肠癌组织中SOCS-3 mRNA的表达[J].中国实验诊断学,2007,11(4):488-490. 被引量：4
  • 3Mingzhen Ying,Dawei Li,Linjun Yang,Mei Wang,Ning Wang,Ying Chen,Miaoxia He,Yajie Wang.Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma[J]. Journal of Cancer Research and Clinical Oncology . 2010 (10)
  • 4Liu WB,Ao L,Zhou Z Y,et al.CpGisland hypermethylationof multiple tumor suppressor genes associated withloss of theirprotein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. Biochemical and Biophysical Research Communications . 2010
  • 5Hernóndez Vargas P,López Franco O,Sanjuón G,et al.Sup-pressors of cytokine signaling regulate angiotensinⅡ-activatedJanus kinase-signal transducers and activators of transcriptionpathway in renal cells. Journal of the American Society of Nephrology . 2005
  • 6Tsukada J,Ozaki A,Hanada T,et al.The role of suppressorof cytokine signaling 1 as a negative regulator for aberrant ex-pansion of CD8alpha+dendritic cell subset. Int I mmunol . 2005
  • 7Brender C,Lovato P,Sommer V H,et al.Constitutive SOCS-3expressin protects T-cell lymphoma against growth inhibitionby IFNalpha. Leukemia . 2005
  • 8Sasi W,Jiang W G,Sharma A,et al.Higher expression levelsof SOCS 1,3,4,7 are associated with earlier tumour stage andbetter clinical outcome in human breast cancer. BMC Canc-er . 2010
  • 9Ahtiainen L,Mirantes C,Jahkola T,et al.Defectsininnatei m-munity render breast cancer initiating cells permissive to onco-lytic adenovirus. PLoS One . 2010
  • 10O’Shea JJ,Gadina M,Schreiber RD.Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell . 2002

二级参考文献22

  • 1贾芙蓉,周劲松,张哲雄,何成彦,刘伟林,赵运,姜喜远,王凤华.SOCS-3 mRNA在胃癌组织及胃癌细胞系中的表达[J].中国实验诊断学,2006,10(5):446-448. 被引量：4
  • 2Biao He,Hang You et al.SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer[J].Proc Natl Acad Sci U S,2003,100(24):14133.
  • 3Farabegoli F,Ceccarelli C,Santini D,et al.Suppressor of cytokine signalling2 (SOCS-2) expression in breast carcinoma[J].J Clin Pathol,2005,58(10):1046.
  • 4Lee H,Yu H.Methylation of Statl promoter can contribute to squamous cell carcinogenesis[J].J Natl Cancer lnst,2006,98(3):154.
  • 5Corvinus FM,Orth C,Moriggl R,et al.Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth[J].Neoplasia,2005,7(6):545.
  • 6Brnder C,Nielsen M,Kaltoft K,et al.STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma[J].Blood,2001,97(2):1056.
  • 7Niwa Y,Kanda H,Shikauchi Y,et al.Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma[J].Oncogene,2005,24(42):6406.
  • 8Rigby RJ,Simmons JG,Greenhalgy CJ,et al.Suppressor of cytokine signaling 3(SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon.Oncogene,2007,26(33):4833-4841.
  • 9Sutherland KD,Vaillant F,Alexander WS,et al.c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3.EMBO J,2006,25(24):5805-5815.
  • 10Ogata H,Kobayashi T,Chinen T,et al.Deletion of the SOCS3 gene in liver parenehymal cells promotes hepatitis-induced hepatocarcinogenesis.Gastroenterology,2006,131(1):179-193.

共引文献4

南昌大学学报（医学版）
2011年 第4期

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