期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

埃博霉素B、D及其衍生物的研究进展 被引量：3

Research progress of epothilone B,D and their derivatives
下载PDF
导出
摘要 埃博霉素是以微管为靶点的大环内酯类药物。已经或正在开发的几种埃博霉素类药物有:埃博霉素B内酰胺衍生物、埃博霉素D、埃博霉素B、埃博霉素F、埃博霉素A,其中埃博霉素D内酰胺衍生物极有可能成为高效候选抗肿瘤新药。本文从结构特点和作用机制出发,重点综述埃博霉素B、D及其衍生物的研发进展。 Epothilones are natural macrolides targeting microtubule.The epothilones which have been or are being developed are aza-epothilone B,epothilone D,epothilone B,epothilone F,epothilone A.Aza-epothilone D has high potential to become an effective candidate of antitumor agent.From the structure and mechanism,this review summarizes the research progress of epothilone B,D and their derivatives.
作者 王利军 胡海峰
机构地区 中国医药工业研究总院 上海医药工业研究院
出处 《世界临床药物》 CAS 2011年第7期416-419,共4页 World Clinical Drug
关键词 埃博霉素B 埃博霉素D 埃博霉素衍生物 生物合成 epothilone B epothilone D derivative biosynthesis
分类号 R979.14 [医药卫生—药品]
  • 相关文献

参考文献23

  • 1Gerth K, Bedorf N, H6fle G, et al. Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria) production, physico-chemical and biological properties [J]. J Antibiot, 1996, 49 (6) : 560-563.
  • 2Hofle G, Bedorf N, Steinmetz H, et al. Epothilone A and B-novel 16-membered macrolides with cytotoxic activity: Isolation, crystal structure, and conformation in solution [J]. Angew Chem (Int Ed Engl), 1996, 35 (13-14) : 1567-1569.
  • 3Kolman A. Activity of epothilones [J]. Curr Opin Investig Drugs, 2005, 6 (6): 616-622.
  • 4Kamath K, Jordan MA. Suppression of microtubule dynamics by epothilone B is associated with mitotic arrest [J]. Cancer Res, 2003, 63 (18):6026-6031.
  • 5Fumoleau P, Coudert B, Isambert N, et al. Novel tubulin- targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues [J]. Ann Oncol, 2007, 18 (Suppl 5): v9-15.
  • 6阎家麒.埃坡西龙(epothilones)化学生物学、全合成产业化及新药临床研究[C].首届中国生物工程应用技术论坛资料汇编,北京,2004:136.
  • 7阎家麒,张文凯.埃博霉素的生物合成[J].国外医药（抗生素分册）,2009,30(3):97-105. 被引量：3
  • 8Nettles JH, Li H, Cornett B, et al. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography[J]. Science, 2004, 305 (5685) : 866-869.
  • 9邱荣国.治疗肿瘤和血管再狭窄的微管稳定剂埃坡霉素:CN,1629283A[P].2005-06-22.
  • 10阎家麒.埃博霉素B内酰胺衍生物的制备方法CNl01323869[P].2008-12-17.

二级参考文献34

  • 1U S FDA, FDA approves ixabepilone for injection(lxempra) for two indications [ EB/OL ]. [ 2007 - 08 - 18 ], http:// www, fda. gov/cder/Offices/OODP/whatsnew/ixabepilone. htm.
  • 2LI W S, THORNTON J E, GUO Z R, et al. A process for the preparation of epothilone analogs and intermediates: WO, 2002/060904 [ P]. 2002 - 08 - 08.
  • 3KIM S H, BORZILLERI R M. A process for the preparation of rlng-opened epothilone intermediates which are useful for the preparation of epothilone analogs: WO, 1999/27890 [ P]. 1999 - 06 - 10.
  • 4BORZILLERI R M, ZHENG X, SCHMIDT R J, et al. A novel application of a Pd(0)-catalyzed nucleophilic substitution reaction to the regioand stereoselective synthesis of lactam analogues of the epothilone natural products[J] .J Am Chem Soc, 2000, 122 (37) :8890- 8897.
  • 5阎家麒.天然产物埃坡西龙B内酰胺衍生物的合成方法:CN,1554659[P].2004-12-15.
  • 6阎家麒.埃博霉素的生物合成与埃博霉素D衍生物的半合成[D].2008中国药学会学术年会暨第八届药师周论文集,2008年石家庄.
  • 7Hofle GH,Bedorf H,Steinmetz H,et al.Epothilone A and B-Novel 16-membered macrolides with cytotoxic activity:isolation,crystal structure,and conformation in solution[J].Angew Chem Int Ed Engl,1996,35:1567.
  • 8girth K,Bedorf N,Hofle G,et al.Epothilone A and B:antifungal and cytotoxic compounds from Sorangium cellulosum(Myxobacteria)production,physicochemical and biological properities[J].J Antibiol,1996,49:560.
  • 9Hofle G,Glaser N,Leibold T,et al.Semisynthesis and degradation of the tubulin inhibitors epothilone and tubulysin[J].Pure Appl Chem,2003,75:167.
  • 10阎家麒.埃坡西龙(epothilones)化学生物学、全合成产业化及新药临床研究[C].首届中国生物工程应用技术论坛资料汇编,北京,2004:136.

共引文献8

同被引文献25

  • 1朱华清,廖润华,梁立强.多孔陶瓷的微生物固定化性能分析及探讨[J].中国陶瓷工业,2005,12(6):22-25. 被引量：10
  • 2赵玉华,贾莹,张旭.改性滤料去除有机物静态吸附试验研究[J].沈阳建筑大学学报（自然科学版）,2007,23(5):814-817. 被引量：14
  • 3Roche H,Yelle L,Cognetti F,et al.Phase clinical trial of ixabepilone (BMS-247550),an epothilone B analog,as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy[J].J Clin Oncol,2007,25(23):3415-3420.
  • 4Davies J,Ryan K S.Introducing the parvome:Bioactive compounds in the microbial world[J].ACS Chem Biol,2012,7 (2):252-259.
  • 5Ochi K,Hosaka T.New strategies for drug discovery:Activation of silent or weakly expressed microbial gene clusters[J].Appl Microbiol Biotechnol,2013,97 (1):87-98.
  • 6Li Z F,Li Y Z.Evolutionary diversity of ketoacyl synthases in cellulolytic myxobacterium Sorangium[J].Syst Appl Microbiol,2007,30:189-196.
  • 7Kwan D H,Schulz F.The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases[J].Molecules,2011,16(7):6092-115.
  • 8Dworkin M.Recent advances in the social and developmental biology of the Myxobacteria[J].Microbiol Revs,1996,60:70-102.
  • 9Diez J,Martinez J P,Mestres J,et al.Myxobacteria:natural pharmaceutical factories[J].Microb Cell Fact,2012,11:52-54.
  • 10Catarina A,Tomas B,Pedro M F,et al.Use of two different carriers in a packed bed reactor for endopolygalacturonase production by a yeast strain[J].Process Biochemistry,2005,40 (5):1937-1942.

引证文献3

二级引证文献8

世界临床药物
2011年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部