顺序性四联免疫抑制方案在肾移植中的初步应用

Preliminary clinical application of sequential quadruple immunosuppressive strategy in renal transplantation

目的：探讨顺序性四联免疫抑制方案在肾移植中的临床疗效。方法：对3例尸肾移植近期内使用骁悉（MMF）和短期小剂量ATG／CsA顺序性四联免疫抑制方案作为诱导免疫抑制方法观察肾功能恢复及急性排斥（AR）情况。结果：该3例术后第3d血肌酐均＜165μmol／L，说明移植肾功能恢复较快。术后对天内无出现AR、CsA肾中毒、感染等并发症。随防7mo－11mo，健康情况良好。结论：在肾移植功能即刻恢复者，预防性使用MMF、短期小剂量ATG／CsA顺序性四联方案可能是一种安全有效的免疫抑制方案。

objective:To probe inte the clinical effeCtiveness of sequential quadruple immunosuppressive strategy in recipient of renal transplantion. Methods: The meovery levels of renal ed function and the acute - rejection rates were observed for 3 cases of cadaver renal transplant applied with quadruple immunosuppressive straegy with sequenhal MMF and low dosage of ATG/CsA in short-term shortly after operation. Results: 3 patients were treated with Scr < 165μmol/L 3 days postoperation, as a result renal grafdrichon recovered more quickly and no acute graft rejection, acute CsA nephrototicity, infection and related complicahons within 30 days after operation occurmd. Conclusion: To the recipient with imrndiate graf ftmction, prophylactic application of quadruple immunosuppressive strategy with sequential MMF and low dosage of ATG/CsA in eary-stage after operation theght be a safe and effective therapy.