乳腺癌中P53,nm23蛋白的表达及临床病理意义

The Expression of the P53 & nm23 Protein in Breast Cancer and its Clinical Pathological Significance

目的探讨乳腺癌中P53,nm23蛋白表达水平及临床病理意义。方法采用免疫组化方法对原发乳腺癌标本进行P53和nm23蛋白检测,检测结果按照年龄、肿物大小、病理学分型、分化程度和淋巴结转移等分组统计分析,组间显著性差异采用x2检验。结果 P53蛋白阳性表达与患者年龄、肿物大小和淋巴结转移无关,但与乳腺癌病理学分型和分化程度关联密切;nm23蛋白表达与患者年龄、癌肿病理分型及分化程度无关,但与癌肿大小和转移有密切关联。结论根据nm23检测结果筛选具有转移危险的患者,早期实施化、放疗;根据P53检测结果,早期预测乳腺癌患者肿瘤细胞分化程度。综合二者检测结果对判断乳腺癌预后具有积极的临床价值。

Objective To explore the expression level of the p53 nm23 protein in breast cancer and its clinical pathological significance.Methods After the p53 an nm23 protein test,patients were statistically classified according to age,size of the tumor,pathological types,proliferation level,lymphatic metastasis etc,and difference significance between teams were done with x2 test.Results P53 protein positive expression is not related to age,tumor size,or lymphatic metastasis,however,it is related to pathological types and proliferation level;nm23 protein expression is not connected with age,pathological types,or proliferation level,but is closely related to tumor size or proliferation.Conclusions If the patients has been confirmed the danger of metastasis after the nm23 test,chemotherapy and radiotherapy should be done in the early stage;according to the P53 test result,the proliferation degree of cancer cells can be predicted in the early stage;if the 2 tests can be combined together,they will provide positive clinical effect for predicting the prognosis of breast cancer.