(-)-棉酚及(-)-醋酸棉酚原料药的稳定性研究

Stability of Raw Medicine of(-)-Gossypol and(-)-Gossypol Acetic Acid

考察(-)-棉酚及(-)-醋酸棉酚原料药的稳定性,为该药原料标准制定及新制剂的研究奠定理论基础。建立(-)-棉酚及(-)-醋酸棉酚原料药的理化鉴别和含量测定方法,并以相关评价指标为依据考察其稳定性。结果显示,本品对高热、高湿、光照均不稳定。由此可知,本品应置于避光、阴凉、干燥处保存。

To investigate the stability of Raw.of（-）-gossypol and（-）-gossypol acetic acid so as to institute raw material standard and provide the theoretical foundation for development of new preparation.Method To establish the characterization method and assay method of（-）-gossypol and（-）-gossypol acetic acid,the stability was investigated on the base of correlated evaluation index.The preparation was unstable under the high fever,humidity and light.The preparation should be protect from light and preserved in cool and dry place.