期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

低糖基化IgA1在IgA肾病中的作用 被引量：1

下载PDF
导出
摘要 IgA肾病是最常见的一种原发性肾小球。肾炎，在我国是导致终末期肾衰竭的重要原因之一。IgA肾病是以多聚体IgA1（polymeride IgA1，pIgA1）为主，包括其他免疫球蛋白和补体沉积于肾小球系膜区，并引起肾小球损伤为特点的肾小球肾炎。IgA1是IgA的一个亚群，其结构特点是具有高度的糖基化，表现在铰链区同时存在N-连接和O-连接糖链。目前，对于IgA肾病的病因及发病机制仍然不明确，近年来，IgA1分子的异常糖基化结构在IgA肾病中的作用引起广泛关注，故本文就异常糖基化IgA1在IgA肾病中的发病机制进行综述。
作者 白雅雯（综述） 饶向荣（审校）
机构地区 内蒙古医学院中医学院
出处 《临床肾脏病杂志》 2011年第7期334-336,共3页 Journal Of Clinical Nephrology
关键词 低糖基化IgA1 IGA肾病 肾小球系膜区 肾小球肾炎 终末期肾衰竭 发病机制 免疫球蛋白 肾小球损伤
分类号 R692.39 [医药卫生—泌尿科学]
  • 相关文献

参考文献20

  • 1Woof JM, Kerr MA. IgA function-variations on a theme. Immu- nology, 2004,113 : 175-177.
  • 2Tarelli E, Smith AC, Hendry BM, et al. Human serum IgA1 is substituted with up to six O-glyeans as shown by matrix assisted laser desorption ionisation time-of-flight mass spectrometry. Car- bohydr Res, 201)4,339 : 2329-2335.
  • 3Moldoveanu Z, Wyatt RJ, Lee JY, et al. Patients with IgA ne- phropathy have increased serum galactose-deficient IgA1 levels. Kidney Int,2007~71:1148-1154.
  • 4Allen AC, Bailey EM, Brenchley PE, et al. Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glyeosylation: observations in three patients. Kidney Int, 2001,60: 969-973.
  • 5Itoh A,Iwase H,Takatani T, et al. Tonsillar IgA1 as a possible source of hypoglycosylated lgA1 in the serum of IgA nephropa- tby patients. Nephrol Dial Transplant, 2003,18 : 1108-1114.
  • 6Iwasaki H, Zhang Y,Tachibana K, et al. Initiation of O-glycan- synthesis in IgAl hinge region is determined by a single enzyme, UDP-N-acetyl-a-D-galactosamine: polypeptide N-acetylgalac- tosaminvltrans~erase 2..1 Biol Chem, 2003,278.. 5613-5621.
  • 7Ju T, Cummings RD. Protein glycosylation: chaperone mutation in Tn syndrome. Nature, 2005,437 : 1252.
  • 8Raska M, Moldoveanu Z, Suzuki H, et al. Identification and char- acterization of CMP-NeuAc~GalNAc-IgA1 a2,6-sialyltransferase in IgAl-producing cells. J Mol Biol, 2007,369 : 69-78.
  • 9Hitoshi Suzuki, Zina Moldoveanu. IgAl-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. J Clin Invest, 2008,118 : 629-639.
  • 10Leung JC,Tsang AW, Chan DT, et al. Absence of CD89, poly- meric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells. J Am Soc Nephrol, 2000, 11 : 241-249.

二级参考文献13

  • 1张宏.IgA肾病的分子遗传学研究[J].中华肾脏病杂志,2005,21(11):641-644. 被引量：12
  • 2聂广俊,李贵森,张宏.IgA肾病患者C1GALT1C1基因的体细胞突变筛查[J].中华肾脏病杂志,2007,23(5):288-291. 被引量：4
  • 3Barratt J, Feehally J. IgA nephropathy. J Am Soc Nephrol, 2005,16:2088-2097.
  • 4Allen AC, Topham PS, Harper SJ, et al. Leucocyte beta 1,3 galactosyhransferase activity in IgA nephropathy. Nephrol Dial Transplant, 1997,12:701-706.
  • 5Qin w, Zhou Q, Yang LC, et al. Peripheral B lymphocyte beta1, 3-galactosyhransferase and chaperone expression in immunoglobulin A nephropathy. J Intern Med, 2005,258: 467-477.
  • 6Pfaffl MW. A mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res, 2001,29:e45.
  • 7Xu LX, Zhao MH. Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy. Kidney Int, 2005, 68:167-172.
  • 8Ju T, Cummings RD. A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3- galactosyhransferase. Proc Natl Acad Sci USA, 2002,99: 16613-16618.
  • 9Ju T, Cummings RD. Protein glycosylation: chaperone mutation in Tn syndrome. Nature, 2005,437(7063):1252.
  • 10Suzuki S, Fujieda S, Sunaga H, et al. Synthesis of immunoglobulins against haemophilus parainfluenzae by tonsillar lymphocytes from patients with IgA nephropathy. Nephrol Dial Transplant, 2000,15:619-624.

共引文献2

同被引文献14

  • 1陈香美,谢院生.IgA肾病的发病与治疗[J].中国中西医结合肾病杂志,2006,7(12):683-686. 被引量：30
  • 2Moldoveanu Z, Wyatt RJ, Lee JY, et al. Patients with IgA ne- phropathy have increased serum galactose-deficient IgA1 levels [ J ]. Kidney Int, 2007,71 ( 11 ) : 1148-1154.
  • 3Shimozato S, Hiki Y, Odani H, et al. Serum under-galactosy IgA1 is increased in Japanese patients with IgA nephropathy[ J]. Neph- rol Dial Transplant, 2008,23 (6) : 1931-1939.
  • 4Gharavi AG, Moldoveanu Z, Wyatt RJ, et al. Abberant IgA1 gly- cosylation is inherited in familial and sporadic IgA nephropathy [J]. J Am Soc Nephrol, 2008,19(5) :1008-1014.
  • 5Lin X, Ding J, Zhu L, et al. Abberant galactosylation of IgA1 is involved in the genetic susceptibility of chinese patients with IgA nephropathy [ J ]. Nephrol Dial Transplant, 2009,24 ( 11 ) : 3372- 3375.
  • 6Xia L, Mcever RP. Targeted disruption of the gene encoding core 1 betal-3- galactosyhransferase ( T-synthase ) causes embryonic le- thality and defective angiogenesis in mice [ J ]. Methods Enzymol, 2006,416:314-331.
  • 7Bertinetto FE, Calafell F, Roggero S, et al. Search for genetic as- sociation between IgA nephropathy and candidate genes selected by function or by gene mapping at loci IgAN2 and IgAN3 [ J]. Nephrol Dial Transplant, 2012,27(6) :2328-2337.
  • 8Wang W, Sun Y, Fu Y, et al. Interaction of C1GALTI-ILSRA on the susceptibility to IgA nephropathy in Southern Han Chinese [ J ]. J Hum Genet, 2013,58 ( 1 ) :40-46.
  • 9Vuong MT, Lundberg S, Gunnarsson I, et al. Genetic variation in the transforming growth factor-131 gene is associated with suscepti- bility to IgA nephropath [ J ]. Nephrol Dial Transplant, 2009,24 (10) :3061-3067.
  • 10Li GS, Zhang H, Lv JC, et al. Variants of C1GALT1 gene are as- sociated with the genetic susceptibility to IgA nephropathy [ J ]. Kidney Int, 2007,71 (5) :448-453.

引证文献1

二级引证文献2

临床肾脏病杂志
2011年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部