摘要
目的:建立RP-HPLC法测定复方二氧丙嗪茶碱片中盐酸二氧丙嗪的含量及含量均匀度。方法:色谱柱为Agilent-C_(18)(150mm×4.6mm,5μm)柱;流动相为水-乙腈-三乙胺(90:10:0.2);流速为1.0ml·min^(-1);检测波长:226nm。结果:盐酸二氧丙嗪在5.04~100.76μg·ml^(-1)范围内线性关系良好(r=0.9997);平均加样回收率为99.04%,RSD=0.17%(n=9)。结论:本法专属性强,操作简便,结果准确可靠。
To establish a method for the determination of content and content uniformity of dioxopromethazine in compound dioxopromethazine hydrochloride tablets by RP-HPLC. Method: The column was Agilent-Cls (150mm × 4. 6mm,5 μm) with wa- ter - acetontrile - triethylamine (90: 10: 0. 2) as the mobile phase at a flow rate of 1.0 ml·min^-1 and UV detection wavelength was at 226 nm. Result: The linear range of dioxopromethazine was 5.04-100. 76μg.m1^-1. The average recovery was 99. 04% , RSD =0. 17 ( n = 9 ). Conclusion : This method is specific, simple and accurate.
出处
《中国药师》
CAS
2011年第7期983-984,共2页
China Pharmacist