芸香苷的胃粘膜保护作用与抗氧化作用的关系

Relationship between protective effects of rutoside on gastric mucosa and antioxidative effects

目的 研究芸香苷(Ru)的胃粘膜保护作用与抗氧化作用的关系。方法 利用大鼠冷冻—束缚应激模型,测定胃粘膜中黄嘌呤氧化酶(XO)活性、还原型谷胱甘肽(GSH)含量,并观察了Ru与抗氧化剂(超氧化物歧化酶,别嘌呤醇、二甲基亚砜)联合用药对胃粘膜损伤的影响。结果 Ru(5、20mg·kg-1,每天2次,共5天,ig)在减轻大鼠冷冻—束缚应激引起的胃粘膜损伤的同时,抑制胃粘膜XO活性,提高胃粘膜GSH含量,Ru还可提高抗氧化剂的胃粘膜保护作用。结论 Ru可以明显减轻大鼠应激性胃粘膜损伤,抗氧化作用是它的可能机制。

Objective To study the relationship between protective effects of rutoside(Ru) on gastric mucosa and antioxdative effects. Methods The rat model of restrain cold stress (RCS) was used to examine xanthine oxidase (XO) activity, the contents of GSH in gastric mucosa and changes of gastric mucosal injury after the synergism between Ru and antioxygen were observed. Results Ru (5, 20 mg·kg -1 ,bid,ig) markedly inhibited the gastric mucosal injury induced by RCS, enhanced the contents of GSH, and inhibited XO activity. Ru could also enhance the gastric mucosal protective effects of antioxygen. Conclusion Ru had protective effect on gastric mucosa of rats, the protective effects might be partially related to its antioxidative effects.