肝硬化时血清透明质酸层粘蛋白Ⅳ型胶原含量的变化

Variations of hyaluronic acid, laminin and type Ⅳ collagen in the sera of patients with liver cirrhosis

目的 对119例肝硬化患者血清中透明质酸(HA)、层粘蛋白(LN)、Ⅳ型胶原(Ⅳ.C)三项肝纤维化血清学指标含量进行检测,探讨其对肝硬化诊断及预后判断的价值。方法 采用放射免疫法(RIA)联合检测已确诊的肝硬化患者血清中HA、LN、ⅣC含量与肝纤维化严重程度(ChildPugh积分分级)进行比较,作相关性分析。结果 肝硬化患者血清中HA、LN、ⅣC含量明显高于正常人及慢性肝炎组(P<001),且三项肝纤维化指标升高的程度与ChildPugh积分分级呈正相关(P<001)。结论 联合检测肝硬化患者血清中HA、LN、ⅣC含量,可作为肝硬化诊断及病情程度判断较可靠的指标。

Objective The serum levels of HA, LN and Ⅳ Collagen in 119 patients with liver cirrhosis were measured to demonstrate the diagnostic and prognostic values of hyaluronic acid (HA), laminin (LN) and type Ⅳ collagen (Ⅳ C) in liver cirrhosis. Methods HA, LN and Ⅳ C in the serum of the patients were measured with RIA, compared with seriousness levels (Child Pughs grades and scores) of hepatic fibrosis, and their relationship analysed respectively. Results The contents of HA, LN and Ⅳ C were higher than those of the normal men and chronic hepatitis ( P< 0 01), and a positive correlation was found between serum HA, LN, Ⅳ C levels and Child Pughs grades and scores ( P< 0 01). Conclusion Measuring concurrently the serum levels of HA, LN, Ⅳ C in patients with liver cirrhosis is reliable in diagnosing of liver fibrosis and judging severity of the disease.