血清心肌肌钙蛋白T变化在烧伤后心肌损伤诊断中的应用

The measurement of cardiac troponin T fore diagnosis of postburn cardiac injury

目的 探索心肌肌钙蛋白T(cTnT)变化在烧伤后心肌损伤诊断中的应用。方法 复制大鼠30%TBSAⅢ度烫伤动物模型,观察烫伤前及烫伤后不同时相点血清cTnT、心肌酶谱(CK、LDH)含量变化。结果 cTnT于伤后1h显著上升,12h比对照值升高43倍,至72h仍保持在高水平;而LDH、CK分别于伤后3h、6h开始上升,至72h已接近正常(P>005)。结论 cTnT与CK、LDH比较,具有出现早、高特异、高灵敏等特点,是诊断烧伤后心肌损伤的可靠指标。

Objective To explore the changes in cardiac troponin T contents for diagnosis of injury postburn myocardial. Methods Wistar rats with 30% TBSA Ⅲ° degree scald were used. 56 adult rats were randomly divided into 8 groups: normal control group, 1,3,6,12,24,48,72 h after scald. The following indicatorswere observed at each rat: the contents of cardiac troponin T and myocardial enzyme spectrum (CK、LDH) in serum. Results The cTnT contents in serum increased markedly at 1st hour and about 43 times higher than control value at 12th hour, remaining at high level at 72nd hour after scald. While LDH and CK activities were increased at 3rd hour and 6th hour respectively, reaching to control level at 72nd hour after scald ( P> 0 05). Conclusion cTnT can be used as a reliable index in the diagnosis of postburn myocardial injury with higher specifity and sensitivity than myocardial enzyme spectrum.