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利用珍贵橙色束丝放线菌ATCC31565氨甲酰基化4,5-双氢-7-去氨甲酰基格尔德霉素 被引量：1

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摘要 格尔德霉素（geldanamycin，GDM）和安丝菌素（ansamitocin，ASM）分别是由吸水链霉菌（如streptomyces hygroscopicus17997）和珍贵橙色束丝放线菌（如actinosynnema pretiosum ATCC31565）产生的具有抗肿瘤活性的安莎类抗生素.
作者 刘昕 李书芬 牛沂菲 贾长虹 武临专 王以光
机构地区 中国医学科学院医药生物技术研究所卫生部抗生素生物工程重点实验室
出处 《中国医药生物技术》 CSCD 2011年第4期302-304,共3页 Chinese Medicinal Biotechnology
基金 "重大新药创制"科技重大专项(2009ZX09501-008)
关键词 格尔德霉素 放线菌 酰基化 甲酰基 去氨 安莎类抗生素 吸水链霉菌 抗肿瘤活性
分类号 R914 [医药卫生—药物化学]
  • 相关文献

参考文献13

  • 1Fulston M, Stefanska AL, Thirkettle JE. Methods for ansamitocin production: US, 6573074. 2003-06-03.
  • 2BeBoer C, Dietz A. The description and antibiotic production of Streptomyces hygroscopicus var. Geldanus. J Antibiot (Tokyo), 1976, 29(11):1182-1188.
  • 3Rascher A, Hu Z, Viswanathan N, et al. Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602. FEMS Microbiol Lett, 2003, 218(2): 223-230.
  • 4Yu TW, Bai L, Clade D, et al. The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum. Proc Natl Acad Sci U S A, 2002, 99(12):7968-7973.
  • 5Zhao P, Bai L, Ma J, et al. Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. Chem Biol, 2008, 15(8):863- 874.
  • 6Hong YS, Lee D, Kim W, et al. Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin. J Am Chem Soc, 2004, 126(36):11142-11143.
  • 7He W, Wu L, Gao Q, et al. Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997. Curr Microbiol, 2006, 52(3):197-203.
  • 8Lin L, He WQ, Wang YG. A new 19-O-glycylated GDM in gdmP mutant of Streptomyces hygroscopicus 17997. Abstract Book of 15th Intemational Symposium on the Biology of Actinomycetes, Shanghai. 2009:51.
  • 9Shin JC, Na Z, Lee DH, et al. Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427. J Microbiol Biotechnol, 2008, 18(6):1101-1108.
  • 10刘爱明,武临专,王以光,张会图,赫卫清,李永海,张侃.苯安莎类抗生素的一种早期鉴别方法[J].中国抗生素杂志,2008,33(7):403-406. 被引量：10

二级参考文献22

  • 1杨红玲,黄为一,杨益平.除莠霉素A结构类似物M3、M4的分离鉴定及对肿瘤细胞的活性[J].中国抗生素杂志,2006,31(5):274-277. 被引量：6
  • 2Rascher A, Hu Z, Viswanathan N, et al. Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602 [J]. FEMS Microbiol Lett, 2003, 218(2):223-230.
  • 3Rascher A, Hu Z, Buchanan G O, et al. Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption[J]. Appl Environ Microbiol, 2005, 71 (8) : 4862 - 4871.
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  • 5Zhang H T, Wu L Z, Liu A M, et al. PCR screening of 3-amino-5-hydroxybenzoic acid synthase gene leads to identification of ansamycins and AHBA related antibiotic producers in actinomycetes[J]. J App Microbiol (in press).
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  • 7Hong Y S, Lee D, Kim W, et al. Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin[J]. J Am Chem Soe, 2004, 126(36): 11142-11143.
  • 8Lee D,Lee K, Cai X F, et al. Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: new insight into the formation of the benzoquinone moiety[J]. Chembiochem, 2006, 7 (2): 246 - 248.
  • 9Schnur R C, Corman M L, Gallaschun R J, et al. erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and ty relationships[J] J Med Chem, 1995,38(19): 3813 - 3820.
  • 10Shin J C, Na Z, Lee D H, et al. Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427[J]. J Microbiol Biotechnol, 2008, 18(6): 1101 - 1108.

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中国医药生物技术
2011年 第4期

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