1Bershad S, Kranjac Singer G, Parente JE, etal. Successful treatment of acne vulgaris using a new method, results of a randomized vehicle - controlled trial of shortcontact therapy with O. 1% tazarotene gel [ J ]. Arch dermatol, 2002,138:481 - 489.
2SHROOT B, MICHEL S. Pharmacology and che-mistry of adapalene[J].J Am Acad Dermatol, 1997, 36(6):S96-S103.
3RUHL R, THIEL R, LACKER T S, et al. Synthesis, high-performance liquid chromatography nuclear magnetic resonance characterization and pharmaco-kinetics in mice of CD271 glucuronide [J]. J Chromatogr B, 2001,757(1):101 - 109.
4OCKER M, HEROLD C, GANSLMAYER M, et al. The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro[J]. Int J Cancer, 2003, 107(3) :453 - 459.
5JOSEPH A M, ROBERT P F. Synthesis of functionally substituted asymmetric biaryls via a novel double metal catalyzed coupling reaction [ J ]. Tetrahedron Lett, 1998, 39(40) :7275 - 7278.
6NEGISHI E I. Palladiumor nickel catalyzed cross-coupling. A new selective method for carbon-carbon bond formation [ J ]. Acc Chem Res, 1982, 15 ( 11 ) : 340 - 348.
7DAWSON M I, CHAIN R L, DERDZINSKI K, et al. Synthesis and pharmacological activity of 6- [ ( E )-2-(2, 6, 6-trimethyl-1-cyclohexen-1-yl)- and 6-( 1,2, 3, 4-tetrahydro- 1, 1, 4, 4-tetramethyl-6-naphthyl )-2 -naphthalenecarboxylic acids[J ]. J Med Chem, 1983, 26(11):1653 - 1656.
8LIU Zhi-cheng, XIANG Jian-nan. A high yield and pilot-scale process for the preparation of adapalene [J]. Org Process Res Dev, 2006, 10(2), 285 - 288.
9PUIG SERRANO J. Process for the preparation of adapalene and related compounds: WO, 2007/ 072217A2[P]. 2007 - 06 - 28.
10CHARPENTIER B, BERNARDON J M, EUSTACHE J, et al. Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes[J]. J Med Chem, 1995,38(6) :4993 - 5006.
1The Council of Europe. European Pharmacopoeia[ S]. 8.0 edi- tion. Strasbourg : The Council of Europe ,2013 : 1485 - 1486.
2GOLLNICK HP, FUNKE G, KORS C, et al. Efficacy of ada- palene/benzoyl peroxide combination in moderate inflammoroty acne and its impact on patient adherence[J].J Dtsch Dermatol Ges,2015,13(6) :557 -565.
3MATTHIAS O, CHRISTOPH H, MARION G, et al. Potentiated anticaneer effects on hepatoma cells by the retinoid adapalene [ J ]. Cancer Lett,2004,208 ( 1 ) : 51 - 58.
4MATTHIAS O,CHRISTOPH H, MARION G,et al. The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro[ J]. lnt J Cancer,2003,107 ( 3 ) : 453 -459.
