^(99)Tc^m亚甲基二膦酸盐联合甲泼尼龙治疗甲状腺相关眼病的疗效观察

Clinical Observation on Technetium (^(99)Tc^m) Methylenediphosphonate combined with Methylprednisolone in the Treatment of Thyroid-associated Ophthalmopathy

目的探讨99 Tcm亚甲基二膦酸盐(99 Tcm-MDP)联合甲泼尼龙治疗甲状腺相关眼病(TAO)的疗效。方法将入选的55例确认为TAO的患者随机分为A、B两组。A组30例为甲泼尼龙冲击治疗组;B组25例为甲泼尼龙联合99Tcm-MDP治疗组。对两组治疗前后的自觉症状、突眼度及甲状腺体积进行统计学分析。结果治疗前后两组患者眼痛、眼胀、畏光、流泪、异物感等自觉症状均有明显改善,突眼度及甲状腺肿大均有显著减轻,而B组较A组在总体疗效、突眼度减轻及甲状腺体积缩小方面效果更佳,两组比较差异有统计学意义。结论 99Tcm-MDP联合甲泼尼龙治疗较单纯甲泼尼龙冲击治疗TAO有更好的效果。

Objective To investigate the curative effect of technetium（99↑Tc^m）methylenediphosphonate（99↑Tc^m-MDP）combined with methylprednisolone in the treatment of thyroid-associated ophthalmopathy（TAO）.Methods 55 cases were divided into two groups randomly：30 cases in group A served as control treated with high-dose methlprednisolone only,25 cases in group B received 99↑Tc^m-MDP combined with high-dose methylprednisolone.Patient′s subjective symptom,the degree of exophthalmos and the thyroid volums were compared before and after the treatment in two groups.Results The efficacy of group B was significantly better than that of group A.The degree of exophthalmos and the thyroid volumes of group A and that of group B were both significant difference before and after the treatment.The average degree of exophthalmos and thyroid volumes in group B were significant difference compared with group A.Conclusion 99↑Tc^m-MDP combined with methylprednisolone therapy is more effective to patients with TAO than high-dose methylprednisolone therapy only.