喹硫平治疗精神分裂症临床观察

Clinical observation of Quetiapine in the treatment of schizophrenia

目的:观察喹硫平治疗精神分裂症的疗效与副作用。方法:对36例精神分裂症患者给予喹硫平治疗8周,以阳性症状与阴性症状量表(PANSS)评定疗效,以不良反应症状量表(TESS)评定药物不良反应。结果:喹硫平治疗后PANSS总分减分率为(70.21±16.46)%,显效时间(10.6±3.5)天,显效率69.4%,有效率91.7%,有效治疗量(357±59)mg/d,未见严重的不良反应,EPS发生率低,安全性好。结论:喹硫平是治疗精神分裂症的有效药物之一,安全性较高。

Objective：To study the effectiveness and sidre of Quetiapine in the treatment of schizophrenia. Methods：Thirty -six patients with schizophrenia were treated with Quetiapine for 8 weeks. PANSS was adopted to determine its effectiveness and TESS was applied to determine its side effects. Results：The score - decreasing rate of PANSS score was （70.21± 16.46） %. The average effectual time was （ 10.6 ± 3.5 ） days,the effectual rate being 69.4%. The effective rate was 91.7%, and the average effective dose was （357 ±59 ）mg/d. ,No severe side effects were observed ,the EPS occurrence tate was low and it was very safe. Conelusion：Quetiapine is effective in treating schizphrenia and it is very safe.