临床分离的283株肠球菌耐药性分析

Analysis on the resistance of 283 strains of clinical isolated enterococci

目的监测临床分离的肠球菌对常用抗菌药物的敏感性,为临床治疗肠球菌感染提供依据。方法常规方法进行菌株分离,应用API strep手工鉴定条进行菌株鉴定,药物敏感试验采用纸片扩散法。结果 2008～2010年分离到常见肠球菌283株,其中尿液57.6%(163株)、分泌物35.0%(99株)、血液4.6%(13株)、胆汁1.1%(3株)、其他标本1.8%(5株);屎肠球菌对青霉素类、万古霉素、替考拉宁、呋喃妥因和喹诺酮类的耐药率明显高于粪肠球菌;而对氯霉素、四环素的耐药性略低于粪肠球菌。结论 肠球菌多重耐药严重,治疗肠球菌感染应针对菌种及耐药特性选择抗生素。

Objective To monitor the sensitivity of clinical isolated against normal antimicrobial drugs,and provide the basis of clinical treatment of enterococcus infections.Methods The strain isolation was done by the conventional methods,and the application API strep manual identification was used to identified the strain,and the drug sensitivity was tested by disk diffusion method.Results 283 strains of enterococci were isolated in 2008-2010,57.6% of them were from urine（n=163）,35.0% of them were from secretion（n=99）,4.5% of them were from blood（n=13）,1.1% of them were from bile（n=3）,and there were 1.8% of them from other specimens（n=5）;the resistance of feces enterococci against to penicillin,vancomycin,teicoplanin,nitrofurantoin and quinolone resistance was significantly higher than that of enterococcus faecalis;while on chloramphenicol,tetracycline,the resistance was slightly lower than that of enterococcus faecalis.Conclusion The multi-drug resistant of enterococci is serious,and enterococcus infection treatment should be selected for bacteria and antibiotic resistan characteristics.