1Nilsson IM, Berntorp E, Lofqvist T, et al. Twenty-five years' experience of prophylactic treatment in severe hae- mophilia A and B[J]. J Intern Med,1992,232(1):25-32.
2Berntorp E, Boulyjenkov V, Brettler D, et al. Modern treatment of haemophilia[J]. Bull World Health Organ, 1995,73(5) :691-701.
3Berntorp E, Astermark J, Bjorkman S, et al. Consensus perspectives on prophylactic therapy for haemophilia: summary statement[J]. Haemophilia, 2003,9 (S1) : 1-4.
4Astermark J,Petrini P,Tengborn L, et al. Primary proph- ylaxis in severe haemophilia should be started at an early age but can he individualized[J]. Br J Haematol, 1999,105 (4) :1109-1113.
5Manco-Johnson MJ, Abshire TC, Shapiro AD, et al. Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia[J]. N Engl J Med,2007,357(6) :535-544.
6Feldman BM, Pai M, Rivard GE, et al. Tailored prophy- laxis in severe hemophilia A..interim results from the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study[J]. J Thromb Haemost,2006,4(6) : 1228-1236.
7Petrini P. What factors should influence the dosage and interval of prophylactic treatment in patients with severe haemophilia A and B[J]? Haemophilia, 2001,7 (1) : 99- 102.
8van den Berg HM,Fiseher K,van der Born JG. Comparing outcomes of different treatment regimens for severe hae- mophilia[J]. Haemophilia,2003,Suppl 1 : 27-31.
9Fischer K, Astermark J,van der Bom JG, et al. Prophylac- tic treatment for severe haemophilia:comparison of an in- termediate-dose to a high-dose regimen[J]. Haemophilia, 2002,8(6) :753-760.
10Fischer K, van der Bom JG, Mauser-Bunschoten EP, et al. The effects of postponing prophylactic treatment on long- term outcome in patients with severe hemophilia[J]. Blood,2002,99(7) :2337-2341.
