探究96例宫颈癌患者术前介入栓塞治疗的临床疗效

The Clinical Curative Effect of 96 Cases of Cervical Cancer Preoperative Intervention in the Embolization Therapy

目的探讨对中期宫颈癌患者在手术前行介入栓塞治疗的临床应用价值。方法在五邑中医院妇科收集96例2006年2月至2010年2月期间住院的中期宫颈癌患者,体力状况良好(PS评分1～2分),心肺功能良好,能耐受肿瘤切除术。随机分为两组,一组为介入治疗组(48例)在手术治疗之前给予患者行微创的介入栓塞治疗;另一组为对照组(48例)仅予以常规手术治疗,记录两组治疗以前的临床症状,介入治疗的不良事件。收集两组的1年和2年生存率,局部复发率,并进行χ2检验的统计学分析。结果两组的人数、临床表现和病情程度,统计分析无显著差异(P>0.05),两组之间具有可比性。介入治疗组和对照组1年和2年生存率分别为94.0%(45/48)、64.0%(31/48)和70.0%(34/48)、46.0%(22/48)做χ2检验的统计学分析后,有统计学差异(χ2=6.62、5.10,P<0.05);局部复发率两组为16.0%(8/48)、40.0%(19/48)做χ2检验的统计学分析后,有统计学差异(χ2=5.89,P<0.05)。结论单纯使用肿瘤手术切除治疗,对于宫颈癌的治疗效果有限,即使是根治性手术,患者的复发率也较高。在手术切除以前,给予患者动脉介入栓塞治疗,可提高根治性手术的切除率,降低患者的临床分期,杀灭部分病灶中的癌细胞,使部分不能手术的患者得到手术切除的机会,效果显著,患者耐受性好,降低的患者的复发转移风险,提高了患者的生活质量,改善患者预后,值得临床推广。

Objective In surgery for intermediate-term cervical cancer patients on intervention embolization value of clinical application.Methods Collecting 96 gynaecology at Wuyi TCM Hospital in February 2006 to February 2010 during the mid-term cervical cancer patients in hospital,physically good（PS score 1-2 points）,cardiopulmonary function is good,tolerated tumor resection.Randomly divided into two groups,one group of interventional treatment group（48 cases）in surgical treatment to patients were done before the intervention embolization minimally invasive;Another group as control group（48 cases）shall be routine surgery,and only two treatment group record before interventional therapy clinical symptoms,the adverse events.Collect two group of 1 year and and 2-year survival,local recurrence rate,and the statistical analysisχ 2 inspection.Results the number of two groups,clinical manifestation and illness degree,statistical analysis no significant difference（P〉0.05）,two groups comparable.Interventional treatment group and control group 1 year and 94.0% respectively and 2-year survival for 45/48）,（64.0%（31/48）and 70.0%（34/48）,46.0%（22/48）do the statistical analysisχ 2 inspection,statistically significant（χ 2 =6.62,5.10）P〈0.05）.Local recurrence rate two groups of room with airconditioning shows 29.2%overproof rate（8/48）,40.0%（19/48）do the statistical analysisχ 2 inspection,statistically significant（χ 2 =5.89,P〈0.05）Conclusion Tumor resection simply use for cervical cancer treatment,the therapeutic effect of limited,even radical surgery,the patient of recurrence was also higher.In the surgical resection,gives patients before arterial embolization,can improve the intervention of radical surgery patients,reducing tupkp clinical stages,kill the cancer cells,make part lesions part cannot surgery patients to get the chance,surgical excision effect significantly,the superior tolerability,reduce the patients of patients relapse and metastasis risk,improve the patient＇s quality of life,improve the prognosis of patients with clinical promotion,worth.