急性心理应激对多囊卵巢综合征患者的影响

Disturbed Stress Responses in Women with Polycystic Ovary Syndrome

为了了解PCOS患者易患抑郁症、肥胖、代谢综合征、心血管疾病、糖尿病的原因。通过对28例PCOS患者和28例体重指数、年龄匹配的健康对照组回应公众演讲压力进行分析,在回应公众演讲压力时,PCOS组和对照组均有比较显著的焦虑程度、ACTH、皮质醇、心率和血压升高(P均<0.01);但PCOS患者焦虑程度、ACTH、皮质醇和心率应激反应显著增强(P均<0.01,时间效应,交互效应);PCOS患者在急性应激时显著减少上调IL-6的水平(P<0.01)。PCOS患者对应激反应的改变可能构成抑郁症、肥胖、代谢综合征、心血管疾病、糖尿病风险之间的联系。

To explore the relationship of polycystic ovary syndrome （PCOS） and depression ,obesity, metabolic syndrome, cardiovascular and diabetes, the responses to public speaking stress were analyzed in 28 PCOS patients and 28 BMI- matched healthy controls. In response to public speaking stress, both groups showed significant but comparable increases in state anxiety, ACTH,cortisol, heart rate and blood pressure （all P〈0.01）; The state anxiety,ACTH,cortisol and heart rate stress responses were significantly enhanced in PCOS （P〈0.01,time effect, interaction effect） ; PCOS patients displayed a reduced upregulation of IL-6 levels in response to stress （P〈0.01）. The altered stress reactivity in PCOS pa tients may constitute a link between depression ,obesity, metabolic syndrome, cardiovascular and diabetes risks associated with the diagnosis.