肺癌与肺部感染患者自身抗体谱的特点比较

Autoantibody Profile Comparison in Patients with Lung Cancer or Pulmonary Infection Disease

目的探讨肺癌、肺部感染患者血清抗核抗体(ANA)谱、类风湿因子(RF)的表现特点。方法采用免疫印迹法检测抗核抗体谱,免疫散射比浊法检测类风湿因子,对照分析90例肺癌患者(均经病理组织学或细胞学检查确诊)、100例肺部感染患者及36例健康人血清抗核抗体谱、类风湿因子的表现特点。结果肺癌患者ANA谱阳性率显著高于健康人群,60岁以上老年肺癌患者ANA谱阳性率显著高于同年龄段健康人群及肺部感染患者,同时,60岁以上老年肺癌患者ANA谱阳性率显著高于60岁以下肺癌患者。肺部感染患者ANA谱阳性率在各年龄组间无明显差异,虽然数据表明随年龄增大阳性率增高,但未取得统计学数据支持。RF阳性率各年龄段无明显差异,肺癌患者与肺部感染患者及健康人群相比,亦无明显差异。结论肺癌与抗核抗体谱有关,肺部感染无明显相关。

Objective To investigate the features of auto-antibody（ include Antinuclear antibodies and rheumatoid factor） in the lung cancer patients and pulmonary infection disease patients. Methods Western blotting was used to identify the antinuclear antibodies（ANAs） and immun0turibidimetric assay were used to detect rheumatoid factor（RF）. The features of 90 cases of lung cancer （diagnosed by pathology or cytology）, 100 cases of pulmonary infection disease and 36 cases of health people were compared. Results There was a high positive rate of ANAs in lung cancer group as compared with pulmonary infection disease group and healthy people group, and the significant difference of high positive rate of ANAs presented frequently in people older than 60 years. There was no significant difference of RF among lung cancer and pulmonary infection disease and health people or different age group. Conclusion Lung cancer is positive correlated with ANAs. Pulmonary infection disease was no significant correlation.