妊娠高血压患者不同妊娠期体内凝血状态的变化

The Analysis of Changes in Coagulation of the Patients with Pregnancy-Induced Hypertension

目的探讨妊娠高血压综合征患者凝血指标变化的临床意义。方法选择本院40例妊高征孕妇,并选择同期检测的40例正常孕妇作对照。分别在妊娠中、晚期取血,检测相关凝血指标。结果妊高征组与对照组孕中期各指标比较,差异均无统计学意义(P>0.05);妊高征组与对照组孕晚期各项指标比较,差异均有统计学意义(P<0.05);轻、中、重度妊高征与正常妊娠孕妇凝血指标比较,差异均有统计学意义(P<0.05)。结论对于正常妊娠来说,妊娠晚期呈现高凝状态将有利于产后快速止血,但是对于妊高征患者来说,特别是妊娠晚期患者易出现病理性高凝状态,临床中应该实时监测预防血栓形成。

Objective To investigate clinical significance of changes in coagulation of the patients with pregnancy-induced hypertension. Methods 40 cases of pregnant women with pregnancy-induced hypertension were considered as pregnancy-induced hypertension group（ PIH group） and 40 cases of normal pregnant women as control group. The coagulation indexes of two groups were measured in the second and third trimester of pregnancy. Results There was no significant difference of index in the second trimester between the PIH group and the control group （ P 〉 0.05 ） ; there were significant differences of index in late pregnancy between the PIH group and the control group （ P 〈 0.05 ） ; there were significant differences of coagulation between gestational hypertension, preeclampsia and eclampsia group and the control group （ P 〈 0.05 ）. Conclusion For normal pregnancy, the third trimester of pregnancy showed hypercoagnlable state will be conducive to rapidly stop bleeding after childbirth, but for PIH, and particularly prone to be pathological hypercoagulable state in patients with late pregnancy, and which should be real-time monito- ring in the clinical to prevent thrombotic formation.