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水通道蛋白-4内向整流钾离子通道4.1与癫痫的关系 被引量：2

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摘要 水通道蛋白-4(Aquaporin,AQP4)是一种与水分子跨膜转运有关的膜转运蛋白,广泛分布于机体与水分子快速跨膜转运的部位,在维持机体内水、电解质平衡中发挥着重要作用。内向整流钾离子通4.1(Inwardly rectifying K+channel,Kir4.1),是中枢神经系统内另一种重要的膜蛋白,具有微弱内向整流的性质,其生理功能是通过调节细胞外间隙中过量的K+浓度,维持其内环境的稳定。最新的研究表明,在生理状态下,AQP4与Kir4.1两种膜蛋白不仅在结构上存在相似性,在中枢神经系统内表达一致,而且在功能呈共耦联关系(AQP4介导的快速跨膜水转运与Kir4.1介导的K+跨膜转运呈功能性耦联)。二者互相协同,在中枢神经系统内水、电解质平衡中发挥着重要作用。在病理情况下,AQP4、Kir4.1及AQP4与Kir4.1两者耦联关系分别在癫痫的发生机制中起重要作用,现将相关进展作一综述。
作者 王目纲 孙国柱 刘性强 杨雷方
机构地区 河北医科大学第二医院神经外科
出处 《中华全科医学》 2011年第9期1433-1434,1437,共3页 Chinese Journal of General Practice
基金 河北省自然基金资助项目(C2008001084) 河北省科技厅资助项目(08206123D)
关键词 水通道蛋白-4 内向整流钾离子通道4.1 癫痫
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献22

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二级参考文献22

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共引文献16

同被引文献35

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引证文献2

二级引证文献5

中华全科医学
2011年 第9期

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