实验性糖尿病大鼠建模常用方法

在研究糖尿病的药物治疗当中,建立合适的动物模型是非常重要的,它可以帮助我们了解药物对疾病的防治机制、药物效应和不良反应,为药物的临床应用提供依据。目前糖尿病建模方法有很多,但各具优缺点,所以根据不同的实验需要选择合适的建模方法就显得极为重要。本文就国内常用的几种实验性糖尿病大鼠建模方法的特点及注意事项做一综述。

In studying prevention and treatment of diabetes mellitus （DM）, it is important to utilize diabetic animal models. It can help us to know the prevention and treatment mechanism,drug effects and adverse drug reactions, and can also provide foundation of the clinical use. Now there＇re lots of methods to utilize diabetic animal models, but every one has two sides, so we need to choose different method according to different experiment to utilize a model. In this article, we will review something need to pay attention to and the feature of some common methods of utilizing diabetic animal models in our country.