血清胱抑素C在新生儿窒息后肾损伤早期诊断中的价值

Early diagnostic value of serum cystatin C in kidney injury induced by asphyxia neonatorum

目的探讨血清胱抑素C(Cys-C)在新生儿窒息后肾损伤早期诊断中的价值。方法窒息新生儿40例按Apgar评分标准分为轻度窒息组24例和重度窒息组16例,另选择16例健康足月新生儿作为对照组。用透射免疫比浊法和谷氨酸脱氢酶法测定各组新生儿血清Cys-C、血清肌酐(SCr)和尿素氮(BUN)浓度。结果轻、重度窒息组患儿血清Cys-C、SCr、BUN水平均高于对照组(P<0.01),重度窒息组患儿血清Cys-C、SCr、BUN水平高于轻度窒息组(P<0.05)。轻、重度窒息组血清Cys-C的异常检出率显著高于BUN和SCr的异常检出率(P<0.05)。结论血清Cys-C水平能反映早期肾损伤,可作为新生儿窒息后肾损害早期诊断指标之一。

Objective To study the early diagnostic value of serum cystatin C（Cys-C） in kidney injury induced by asphyxia neonatorum.Methods According to Apgar score standards,forty asphyxial newborns were divided into mild asphyxia group（n=24） and severe asphyxia group（n= 16）,meanwhile,sixteen healthy full-term newborns were chosed as the control group.The levels of Cys-C,serum creatinine（SCr） and blood urea nitrogen（BUN） were detected by turbidimetry method and glutamate dehydrogenase method.Results The serum levels of Cys-C,BUN and SCr in both mild asphyxia group and severe asphyxia group were higher than those in control group（P0.01）,the level of Cys-C in severe asphyxia group was higher than that in mild asphyxia group（P0.05）.The rates of abnormal level of Cys-C were higher than those of BUN and SCr in mild and severe asphyxia groups（P0.05）.Conclusion The serum level of Cys-C can show the damage of kidney early,so it will be as one of the marks on diagnosing the kidney damage induced by asphyxia neonatorum.