吡格列酮干预高胰岛素抗体的高血糖效果观察

The effect of Pioglitazone to intervene insulin antibody in hyperglycemia

目的:研究吡格列酮干预2型糖尿病(T2DM)高胰岛素抗体(insulin antibody,IA)的高血糖效果。方法:26例患者予吡格列酮片45mg/d口服,疗程2周,观察治疗前后空腹血糖(FPG)、餐后2h血糖(2hPG)、IA、体重指数(BMI)、腰臀比(WHR)、胆固醇(TC)、甘油三酯(TG)。结果:治疗后IA降低(P<0.05),FPG和2hPG降低(P<0.01)。结论:较大剂量的吡格列酮治疗可显著降低T2DM的血糖。

Objective： The aim of this study was to research the effects of Pioglitazone to intervene hyperglycaemia of insulin antibody（IA） in type 2 diabetes mellitus（T2DM）. Methods： 26 patients took Pioglitazone （45 mg/d P. O. ） in two weeks, the fasting blood glucose （FBG）, 2-hour post blood glucose （2hPG）,IA, Body Mass Index（BMI）, waist hip rate（WHR）, eholesterol（TC）, triglyceride（TG） changes were observed in two weeks. Results： After treatment, IA was significant difference（P〈0.05） ,FPG and 2hPG were decreased significantly（P〈0.01）. Conclusion： The large dose of Pioglitazone can significantly reduce blood glucose in type 2 diabetes.