五种中成药对局灶性脑缺血损伤的影响及机制比较

Effects and Mechanism of Five Chinese Patent Medicines on Focal Cerebral Ischemia

目的:探讨通塞脉片、通心络胶囊、步长脑心通、复方血栓通胶囊与血塞通胶囊等5种中成药对局灶慢脑缺血损伤大鼠脑缺血损伤的影响及其机制的差异。方法:采用电凝法制备大鼠脑缺血模型,观察5种中成药对脑含水量、脑指数、梗塞率、血清中超氧化物歧化酶(SOD)、丙二醛(MDA)、睾酮(T)、雌二醇(E2)及脑内雌激素受体(ER)表达的影响。结果:局灶性脑缺血模型大鼠脑含水量、脑指数、脑梗塞率均显著升高,MDA、E2含量升高,ER表达上调,SOD活性和T含量下降,各药均能改善模型大鼠脑水肿(除通心络胶囊外)、减少梗塞范围、减少MDA含量、下调ER表达、提高SOD活性;复方血栓通胶囊、血塞通胶囊、通塞脉片能显著增加T的含量,步长脑心通、复方血栓通胶囊、血塞通胶囊能显著降低E2的含量,生长脑心通、通塞脉片。结论:这5种中成药可分别通过不同作用机制对脑缺血损伤起到保护作用。

Objective：To study the differences between the effects of five Chinese patent medicines on focal cerebral ischemia.Tongsaimai Tablet（TSM）,Tongxinluo Capsule（TXL）,Buchangnaoxintong（BCNXT）,Fufangxueshuantong Capsule（FFXST） and Xuesaitong Capsule.Methods：The focal cerebral ischemia rats were modeled by electric coagulation.The water content of brain,cerebral index,cerebral infarction rate,superoxide dismutase（SOD）,malondialdehyde（MDA）,testosterone（T）,estradiol（E2） in serum and expression of estrogen receptor（ER） in brain were detected after adminstration.Results：Compared with the sham group,the water content of brain,cerebral index,cerebral infarction rate the content of MDA and E2 in serum and the ER expression of focal cerebral ischemia rats increased,the activity of SOD and the content of T were decreased.All these five Chinese patent medicines could reduce encephaledema（except TXL） and the infarct range,decrease the content of MDA and the expression of ER.BCNXT and TSM could increase the activify of SOD;FFXST,XST and TSM could increase the content of T;BCNXT,FFXST and XST could decrease the content of E2.Conclusion：The five Chinese patent medicines have the protection effect on cerebral ischemia,but their mechanisms are not exactly the same.