益生菌、胃肠道微生物和宿主之间相互作用的研究进展

Research Advance on the Interaction of Probiotic、 Gut Microflora and Host

目前国内外的研究工作集中于了解肠道共生菌和益生菌以及人类宿主之间的相互作用。利用组学技术,以便于了解益生菌和共生菌之间以及细菌环境和宿主胃肠道组织之间的相互作用。利用测序技术对栖居在胃肠道内细菌的研究显示人体的复杂性随不同人群和个体的变化而变化。此外,转录推动了我们对细菌(包括共生菌和益生菌)与胃肠道间复杂相互作用的洞悉。本综述从胃肠道内微生物的作用等方面概括这一领域的最新研究进展,并在此基础上提出对未来的展望。

Recently researches focus on understanding the interaction between probiotic bacteria and gut bacteria and host in domestic and broad and contribute to their beneficial attributes as a means of determining mechanisms of probiotic functionality. Nowadays,on the one hand we growingly acknowledge the intrinsic interaction between probiotic bacteria and commensal bacteria and between the milieu of bacteria and the host tissues of the gut by using‘omic’technologies. On the other hand surveys of bacterial inhabitanting in the GIT using sequencing technologies have illustrated the complexities of this human organ which varies between different populations and individuals. In addition transcriptomics have promoted an insight into the complex interaction between bacteria（including probiotic and commensal bacteria） and the gastrointestinal tract（GIT） . This summary outlines the recent important advances in this exciting area of research from two aspects such as the role of probiotic bacteria and gut microflora in the GIT,then proposes future outlook.