杂多酸催化合成维生素E乙酸酯的研究

Study of synthesis of Vitamin E acetate using H_3PMo_(12)O_(40) heteropolyacid as catalyst

采用杂多酸H3PMo12O40为催化剂合成了维生素E乙酸酯,考察了温度、时间、反应物配比、催化剂用量等因素对酯化率的影响,并通过模糊数学模型确定了最优合成工艺:温度为40℃,时间为3 h,维生素E的加入量为5 mmol,n(乙酸酐)∶n(维生素E)=1.0∶1,催化剂用量为1.2 g,此时反应的平均酯化率为97.6%。利用IR、元素分析和1HNMR对产物结构进行了表征。

Synthesis of Vitamin E acetate was studied using H3PMo12O40 heteropolyacid as catalyst. The effects of reaction conditions, such as reaction temperature, reaction time, molar ratio of acetic anhydride to Vitamin E and catalyst dosage on conversion were investigated. Fuzzy mathematics model was used to optimize the synthesis conditions. The optimum conditions were determined as follows ： the reaction temperature is 40 ℃, the reaction time is 3 h, the molar ratio of acetic anhydride to Vitamin E is 1.0： 1, and the dosage of catalyst is 1.2 g （5 mmol Vitamin E）. Conversion of Vitamin E achieves 97.6%. The product was characterized by IR, elemental analysis and ^1HNMR.