中学女生外周血前列腺素与原发性痛经关系

Relationship between PGF_(2α) and primary dysmenorrhea in female middle school students

目的通过对中学女生月经期外周血前列腺素(PGF2α)浓度的测定,探讨其与原发性痛经的相关性。方法在1 155名被调查的中学女生中随机抽取241名月经期学生,分为月经来潮﹤48 h痛经组、≥48 h痛经组、月经来潮<48 h无痛经组及≥48 h无痛经组,分别测定其外周血PGF2α浓度。结果月经来潮<48 h痛经组PGF2α浓度明显高于其余3组(P<0.01),月经来潮≥48 h有痛经组PGF2α浓度与无痛经组比较差异有统计学意义(P<0.01),2组无痛经组间PGF2α浓度差异亦有统计学意义(P<0.01),但却无痛经现象。结论 PGF2α与月经来潮48h内的原发性痛经有关,且痛经症状与PGF2α的浓度密切相关。

Objective To study the relationship between primary dysmenorrhea and prostaglandin（PGF2α） concentration of peripheral blood in students in menstrual period.Methods A total of 241 students in menstrual period randomly selected from 1 155 female middle school students were divided into 48 hours dysmenorrhea group,≥ 48 hours dysmenorrhea group,48 hours without dysmenorrhea group,and ≥ 48 hours without dysmenorrhea group.PGF2α concentrations in their peripheral blood were determined.Results The PGF2α levels in the students of 48 hours dysmenorrhea group were significantly higher than those of the other students（P0.01）.There were significant differences in PGF2α level between ≥48 hours dysmenorrhea group and ≥ 48 hours without dysmenorrhea group（P0.01） and between the two groups without dysmenorrhea（P0.01）.Conclusion There is a significant relationship between PGF2α of menstrual period and primary dysmenorrheal,but dysmenorrhea symptoms may closely relate to the concentration of PGF2α.