摘要
目的探讨骨架相关蛋白CapG在胰腺癌组织中的表达及其与胰腺癌发生发展的关系。方法采用免疫组化法检测CapG在60例胰腺癌患者的癌组织、20例癌旁组织(距癌边缘>5cm)中的表达水平,并分析其与临床病理特征的关系。结果 CapG在胰腺癌组织中的表达阳性率为68.3%(41/60),显著高于癌旁组织[30.0%(6/20),P<0.05]。胰腺癌组织中CapG表达与胰腺癌的淋巴结转移及TNM分期密切相关(P<0.05),与性别、年龄、肿瘤大小及分化程度无关(P>0.05)。结论 CapG可能通过促进胰腺癌细胞的运动侵袭能力,参与胰腺癌的转移发生。
Objective To investigate the expression and significance of actin-associated protein CapG in pancreatic cancer.Methods Immunohistochemistry was used to detect the expression of CapG in pancreatic cancer tissues（n=60） ,and adjacent tumor-free tissues（5cm apart from cancer,n=20） .Data associated with clinical pathological characteristics was analyzed.Results The immunohistochemistry examination showed that the expression of CapG was significantly higher in cancerous tissues than that of tumor-free tissues[68.3%（41/60） and 30.0%（6/20） ,P0.05].Overexpression of CapG in cancerous tissues was closely related to lymph node metastasis and TNM staging（both P0.05） .Conclusions CapG may play an important role in development of pancreatic cancer by promoting cancer cell transfer.
出处
《医药论坛杂志》
2011年第10期1-2,6,共3页
Journal of Medical Forum
基金
河南省卫生科技创新型人才工程资助项目(4107)
关键词
胰腺肿瘤
转移
CapG
Pancreatic neoplasms
Metastasis
CapG
