奥氮平对首发精神分裂症患者认知功能的影响

Influences of Olanzapine on cognitive function of first-episode schizophrenics

目的探讨奥氮平对首发精神分裂症患者认知功能的影响。方法对信阳市精神病医院2008年1月至2008年11月60例首发精神分裂症患者,在奥氮平治疗前后进行威斯康星卡片分类测验(WCST)。结果治疗后WSCT总测验次数、持续错误数、非持续错误数均少于治疗前,差异有统计学意义(P<0.05),在研究治疗前后WCST和阳性与阴性症状量表(PANSS)之间相关性时,PANSS总分与总测验次数、持续错误数、非持续错误数呈负相关;阳性症状量表分与总测验次数、持续错误数、非持续错误数呈正相关,与正确反应数呈负相关;而阴性症状量表分与WCST各项指标之间无明显相关关系。结论经奥氮平治疗后,精神分裂症患者在症状改善同时,认知功能也有明显提高,且认知功能的提高与阳性症状的改善存在着明显的相关性,而与阴性症状的改善关系不大,提示两者可能存在异质性。

Objective To explore the influences of Olanzapine on cognitive function of first-episode schizophrenics.Methods Toally 60 first-episode schizophrenics were studied with Wisconsin Card Sorting Test（WCST） before and after 12 weeks being treated with Olanzapine.Results The study showed that patients did better after treatment than before on the total trials,persistent errors and random errors（P0.05） .It was also found that the reduction of positive symptoms score of Positive and Negative Symptoms Scale（PANSS） had significantly positive correlation with the change of the total trials,persistent errors,random errors of WCST and had significantly negative correlation with the correct of WCST（P0.05） ,we also found that the change of scores of negative scale of PANSS had no significant relationship with the change of each index of WCST.Conclusions The study shows that cognitive function of patients is also improved when the schizophrenic symptoms are cured with Olanzapine,the change of the positive symptoms has more correlation with the improvement of cognitive function and the change of negnative symptoms have not significant correlation with the improvement of cognitive function.