左氧氟沙星注射液治疗泌尿系感染疗效分析

Curative efficacy analysis of Levofloxacin Injection in urinary system infection

目的:在PK/PD参数理论指导下,观察左氧氟沙星静滴每日1次和每日2次治疗泌尿系感染的疗效。方法:选取86例泌尿系感染患者,随机分为治疗组和对照组,每组43例,治疗组用左氧氟沙星400 mg,静脉滴注,1次/d,对照组用左氧氟沙星200 mg,静脉滴注,2次/d。结果:用药3 d后两组血和尿中白细胞数、血中性粒细胞数及体温>37℃的病例数比较,差异有统计学意义(P<0.05)。其中,治疗组有效率为95.3%(41/43),对照组为83.7%(36/43),两组有效率比较,差异有统计学意义(P<0.05)。结论:左氧氟沙星治疗泌尿系统感染,静滴每日1次给药疗效优于静滴每日2次。

Objective： To observe the clinical efficiency of Levofloxacin ivgtt qd and bid in urinary system infection under the guide of PK/PD parameters theory.Methods： 86 cases of patients with urinary system infection were randomly divided into two groups,43 cases of patients in treatment group with Levofloxacin 400 mg ivgtt qd;43 cases of patients in control group with Levofloxacin 200 mg ivgtt bid.Results： The counting of WBC in urine and blood,neutrocyte in blood and the case of patients whose temperature over 37℃ after 3 days using of Levofloxacin,were significantly different between the two groups（P〈0.05）.The efficiency rate of treatment group was 95.3% and 83.7% in control group.Conclusion： Levofloxacin ivgtt qd has a better curative effect than ivgtt bid in patients of urinary tract infections.