摘要
建立了高效液相色谱—串联质谱法(LC/MS/MS)测定羊肉中残留的6种磺胺类药物:磺胺喹噁啉(sulfaquinoxaline,SQX)、磺胺嘧啶(sulfadiazine,SDZ)、磺胺二甲氧嘧啶(sulfadimethoxine,SDM)、磺胺间甲氧嘧啶(sulfamonomethoxin,SMM)、磺胺对甲氧嘧啶(sulfameter,SMT)、磺胺甲噁唑(sulfamethoxazole,SMZ)。样品经乙腈匀浆提取,正己烷脱脂后旋转蒸发至近干,氮气吹干,流动相溶解并定容,再用正己烷净化后上机检测,在多反应监测模式下检测,外标法定量。结果表明,6种磺胺质量浓度在10～500μg/L内线性关系良好,相关系数R2为0.998 1～0.999 8,回收率为78%～105%,定量限为10μg/kg。
A method for the determination of six sulphonamides（sulfaquinoxaline,sulfadiazine,sulfadimethoxine,sulfamonomethoxin,sulfameter,sulfamethoxazole） residues in mutton tissue is established.The sample is extracted by acetonitrile and detected by High Performance Liquid Chromatography-tandem mass spectrometer.The results show that the correlation coefficients of linear calibration curves R2=0.998 1～0.999 8 within the sulphonamides concentration range of 10～500 μg/L,the detection limits of this method are 10μg/kg and the recovery rates are 78%～105%.
出处
《农产品加工（下）》
2011年第8期90-92,共3页
Farm Products Processing
关键词
磺胺类药物
残留
液相色谱—串联质谱
羊肉
sulphonamides
residue analysis
liquid chromatography-tandem mass spectrometer
mutton tissue
